Coccidioidomycosis in healthy persons evaluated for liver or kidney donation

J. E. Blair, D. C. Mulligan

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Coccidioidomycosis is a fungal infection caused by Coccidioides species endemic to the southwestern United States, where it poses unique challenges for transplant recipients. Donor-derived coccidioidomycosis has been documented, but its risk of transmission is not known. We prospectively screened 568 healthy persons requesting evaluation for possible liver or kidney donation. Twelve (2.1%) of the 568 donor candidates were seropositive (11 initially and 1 with seroconversion and symptomatic illness within 1 week after negative screening). Three of these 12 patients proceeded to kidney donation, and a fourth patient proceeded to liver donation. None of the 4 transplant recipients received special coccidioidal prophylaxis, although all were administered fluconazole according to standard antifungal prophylaxis protocols. At follow-up (7-54 months), no coccidioidomycosis was identified in any recipient. The prevalence of coccidioidal antibodies was low among potential organ donor candidates, but the risk of donor-derived coccidioidomycosis remains unknown and further study is warranted.

Original languageEnglish (US)
Pages (from-to)78-82
Number of pages5
JournalTransplant Infectious Disease
Volume9
Issue number1
DOIs
StatePublished - Mar 2007

Fingerprint

Coccidioidomycosis
Tissue Donors
Kidney
Liver
Southwestern United States
Coccidioides
Mycoses
Fluconazole
Antibodies
Transplant Recipients

Keywords

  • Coccidioidomycosis
  • Disease transmission
  • Mycoses
  • Prophylaxis
  • Transplants

ASJC Scopus subject areas

  • Transplantation
  • Microbiology (medical)
  • Immunology

Cite this

Coccidioidomycosis in healthy persons evaluated for liver or kidney donation. / Blair, J. E.; Mulligan, D. C.

In: Transplant Infectious Disease, Vol. 9, No. 1, 03.2007, p. 78-82.

Research output: Contribution to journalArticle

Blair, J. E. ; Mulligan, D. C. / Coccidioidomycosis in healthy persons evaluated for liver or kidney donation. In: Transplant Infectious Disease. 2007 ; Vol. 9, No. 1. pp. 78-82.
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