Coccidioidomycosis in healthy persons evaluated for liver or kidney donation

J. E. Blair, D. C. Mulligan

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Coccidioidomycosis is a fungal infection caused by Coccidioides species endemic to the southwestern United States, where it poses unique challenges for transplant recipients. Donor-derived coccidioidomycosis has been documented, but its risk of transmission is not known. We prospectively screened 568 healthy persons requesting evaluation for possible liver or kidney donation. Twelve (2.1%) of the 568 donor candidates were seropositive (11 initially and 1 with seroconversion and symptomatic illness within 1 week after negative screening). Three of these 12 patients proceeded to kidney donation, and a fourth patient proceeded to liver donation. None of the 4 transplant recipients received special coccidioidal prophylaxis, although all were administered fluconazole according to standard antifungal prophylaxis protocols. At follow-up (7-54 months), no coccidioidomycosis was identified in any recipient. The prevalence of coccidioidal antibodies was low among potential organ donor candidates, but the risk of donor-derived coccidioidomycosis remains unknown and further study is warranted.

Original languageEnglish (US)
Pages (from-to)78-82
Number of pages5
JournalTransplant Infectious Disease
Volume9
Issue number1
DOIs
StatePublished - Mar 1 2007

Keywords

  • Coccidioidomycosis
  • Disease transmission
  • Mycoses
  • Prophylaxis
  • Transplants

ASJC Scopus subject areas

  • Transplantation
  • Infectious Diseases

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