Coagulation disorders

Rajiv K. Pruthi, Michelle L. Kluge, Aneel Arjun Ashrani

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

The vascular system is a series of interconnected biologic conduits filled with fluid moving under pressure. This system is subject to injury, with exsanguination avoided by the functions of the hemostatic system. Normal hemostasis is a reparative process and consists of three major mechanisms: (1) vasospasm, (2) platelet plug formation, and (3) the procoagulant system. While inherited or acquired disorders of all three mechanisms can cause clinically abnormal bleeding, this chapter reviews the molecular basis of the more commonly inherited disorders of the procoagulant system (e.g., hemophilia A and B, and von Willebrand disease) associated with abnormal bleeding.

Original languageEnglish (US)
Title of host publicationMolecular Pathology in Clinical Practice
Subtitle of host publicationSecond Edition
PublisherSpringer International Publishing
Pages203-223
Number of pages21
ISBN (Electronic)9783319196749
ISBN (Print)9783319196732
DOIs
StatePublished - Jan 1 2016

Fingerprint

Hemorrhage
Exsanguination
Hemophilia B
von Willebrand Diseases
Hemophilia A
Hemostatics
Hemostasis
Blood Vessels
Blood Platelets
Pressure
Wounds and Injuries

Keywords

  • Bleeding disorder
  • Coagulation
  • Diagnostic testing
  • F2 gene
  • F5 gene
  • F8 gene
  • F9 gene
  • Factor IX deficiency
  • Factor V leiden
  • Factor VIII deficiency
  • Hemophilia A
  • Hemophilia B
  • Homocystinuria
  • Hyperhomocysteinemia
  • Molecular testing
  • Prothrombin
  • Purpura fulminans neonatalis
  • Thrombophilia
  • Venous thrombosis
  • Von willebrand disease
  • VWF gene

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Pruthi, R. K., Kluge, M. L., & Ashrani, A. A. (2016). Coagulation disorders. In Molecular Pathology in Clinical Practice: Second Edition (pp. 203-223). Springer International Publishing. https://doi.org/10.1007/978-3-319-19674-9_15

Coagulation disorders. / Pruthi, Rajiv K.; Kluge, Michelle L.; Ashrani, Aneel Arjun.

Molecular Pathology in Clinical Practice: Second Edition. Springer International Publishing, 2016. p. 203-223.

Research output: Chapter in Book/Report/Conference proceedingChapter

Pruthi, RK, Kluge, ML & Ashrani, AA 2016, Coagulation disorders. in Molecular Pathology in Clinical Practice: Second Edition. Springer International Publishing, pp. 203-223. https://doi.org/10.1007/978-3-319-19674-9_15
Pruthi RK, Kluge ML, Ashrani AA. Coagulation disorders. In Molecular Pathology in Clinical Practice: Second Edition. Springer International Publishing. 2016. p. 203-223 https://doi.org/10.1007/978-3-319-19674-9_15
Pruthi, Rajiv K. ; Kluge, Michelle L. ; Ashrani, Aneel Arjun. / Coagulation disorders. Molecular Pathology in Clinical Practice: Second Edition. Springer International Publishing, 2016. pp. 203-223
@inbook{56e1c00cfb014c94ba1ffecf5095a007,
title = "Coagulation disorders",
abstract = "The vascular system is a series of interconnected biologic conduits filled with fluid moving under pressure. This system is subject to injury, with exsanguination avoided by the functions of the hemostatic system. Normal hemostasis is a reparative process and consists of three major mechanisms: (1) vasospasm, (2) platelet plug formation, and (3) the procoagulant system. While inherited or acquired disorders of all three mechanisms can cause clinically abnormal bleeding, this chapter reviews the molecular basis of the more commonly inherited disorders of the procoagulant system (e.g., hemophilia A and B, and von Willebrand disease) associated with abnormal bleeding.",
keywords = "Bleeding disorder, Coagulation, Diagnostic testing, F2 gene, F5 gene, F8 gene, F9 gene, Factor IX deficiency, Factor V leiden, Factor VIII deficiency, Hemophilia A, Hemophilia B, Homocystinuria, Hyperhomocysteinemia, Molecular testing, Prothrombin, Purpura fulminans neonatalis, Thrombophilia, Venous thrombosis, Von willebrand disease, VWF gene",
author = "Pruthi, {Rajiv K.} and Kluge, {Michelle L.} and Ashrani, {Aneel Arjun}",
year = "2016",
month = "1",
day = "1",
doi = "10.1007/978-3-319-19674-9_15",
language = "English (US)",
isbn = "9783319196732",
pages = "203--223",
booktitle = "Molecular Pathology in Clinical Practice",
publisher = "Springer International Publishing",

}

TY - CHAP

T1 - Coagulation disorders

AU - Pruthi, Rajiv K.

AU - Kluge, Michelle L.

AU - Ashrani, Aneel Arjun

PY - 2016/1/1

Y1 - 2016/1/1

N2 - The vascular system is a series of interconnected biologic conduits filled with fluid moving under pressure. This system is subject to injury, with exsanguination avoided by the functions of the hemostatic system. Normal hemostasis is a reparative process and consists of three major mechanisms: (1) vasospasm, (2) platelet plug formation, and (3) the procoagulant system. While inherited or acquired disorders of all three mechanisms can cause clinically abnormal bleeding, this chapter reviews the molecular basis of the more commonly inherited disorders of the procoagulant system (e.g., hemophilia A and B, and von Willebrand disease) associated with abnormal bleeding.

AB - The vascular system is a series of interconnected biologic conduits filled with fluid moving under pressure. This system is subject to injury, with exsanguination avoided by the functions of the hemostatic system. Normal hemostasis is a reparative process and consists of three major mechanisms: (1) vasospasm, (2) platelet plug formation, and (3) the procoagulant system. While inherited or acquired disorders of all three mechanisms can cause clinically abnormal bleeding, this chapter reviews the molecular basis of the more commonly inherited disorders of the procoagulant system (e.g., hemophilia A and B, and von Willebrand disease) associated with abnormal bleeding.

KW - Bleeding disorder

KW - Coagulation

KW - Diagnostic testing

KW - F2 gene

KW - F5 gene

KW - F8 gene

KW - F9 gene

KW - Factor IX deficiency

KW - Factor V leiden

KW - Factor VIII deficiency

KW - Hemophilia A

KW - Hemophilia B

KW - Homocystinuria

KW - Hyperhomocysteinemia

KW - Molecular testing

KW - Prothrombin

KW - Purpura fulminans neonatalis

KW - Thrombophilia

KW - Venous thrombosis

KW - Von willebrand disease

KW - VWF gene

UR - http://www.scopus.com/inward/record.url?scp=85018686366&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85018686366&partnerID=8YFLogxK

U2 - 10.1007/978-3-319-19674-9_15

DO - 10.1007/978-3-319-19674-9_15

M3 - Chapter

AN - SCOPUS:85018686366

SN - 9783319196732

SP - 203

EP - 223

BT - Molecular Pathology in Clinical Practice

PB - Springer International Publishing

ER -