Coagulation disorders

Rajiv K. Pruthi; Michelle L. Kluge; Aneel Arjun Ashrani

doi:10.1007/978-3-319-19674-9_15

Coagulation disorders

Rajiv K. Pruthi, Michelle L. Kluge, Aneel Arjun Ashrani

Hematology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

The vascular system is a series of interconnected biologic conduits filled with fluid moving under pressure. This system is subject to injury, with exsanguination avoided by the functions of the hemostatic system. Normal hemostasis is a reparative process and consists of three major mechanisms: (1) vasospasm, (2) platelet plug formation, and (3) the procoagulant system. While inherited or acquired disorders of all three mechanisms can cause clinically abnormal bleeding, this chapter reviews the molecular basis of the more commonly inherited disorders of the procoagulant system (e.g., hemophilia A and B, and von Willebrand disease) associated with abnormal bleeding.

Original language	English (US)
Title of host publication	Molecular Pathology in Clinical Practice
Subtitle of host publication	Second Edition
Publisher	Springer International Publishing
Pages	203-223
Number of pages	21
ISBN (Electronic)	9783319196749
ISBN (Print)	9783319196732
DOIs	https://doi.org/10.1007/978-3-319-19674-9_15
State	Published - Jan 1 2016

Keywords

Bleeding disorder
Coagulation
Diagnostic testing
F2 gene
F5 gene
F8 gene
F9 gene
Factor IX deficiency
Factor V leiden
Factor VIII deficiency
Hemophilia A
Hemophilia B
Homocystinuria
Hyperhomocysteinemia
Molecular testing
Prothrombin
Purpura fulminans neonatalis
Thrombophilia
Venous thrombosis
Von willebrand disease
VWF gene

ASJC Scopus subject areas

Medicine(all)

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10.1007/978-3-319-19674-9_15

Cite this

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abstract = "The vascular system is a series of interconnected biologic conduits filled with fluid moving under pressure. This system is subject to injury, with exsanguination avoided by the functions of the hemostatic system. Normal hemostasis is a reparative process and consists of three major mechanisms: (1) vasospasm, (2) platelet plug formation, and (3) the procoagulant system. While inherited or acquired disorders of all three mechanisms can cause clinically abnormal bleeding, this chapter reviews the molecular basis of the more commonly inherited disorders of the procoagulant system (e.g., hemophilia A and B, and von Willebrand disease) associated with abnormal bleeding.",

keywords = "Bleeding disorder, Coagulation, Diagnostic testing, F2 gene, F5 gene, F8 gene, F9 gene, Factor IX deficiency, Factor V leiden, Factor VIII deficiency, Hemophilia A, Hemophilia B, Homocystinuria, Hyperhomocysteinemia, Molecular testing, Prothrombin, Purpura fulminans neonatalis, Thrombophilia, Venous thrombosis, Von willebrand disease, VWF gene",

author = "Pruthi, {Rajiv K.} and Kluge, {Michelle L.} and Ashrani, {Aneel Arjun}",

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doi = "10.1007/978-3-319-19674-9_15",

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AU - Kluge, Michelle L.

AU - Ashrani, Aneel Arjun

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N2 - The vascular system is a series of interconnected biologic conduits filled with fluid moving under pressure. This system is subject to injury, with exsanguination avoided by the functions of the hemostatic system. Normal hemostasis is a reparative process and consists of three major mechanisms: (1) vasospasm, (2) platelet plug formation, and (3) the procoagulant system. While inherited or acquired disorders of all three mechanisms can cause clinically abnormal bleeding, this chapter reviews the molecular basis of the more commonly inherited disorders of the procoagulant system (e.g., hemophilia A and B, and von Willebrand disease) associated with abnormal bleeding.

AB - The vascular system is a series of interconnected biologic conduits filled with fluid moving under pressure. This system is subject to injury, with exsanguination avoided by the functions of the hemostatic system. Normal hemostasis is a reparative process and consists of three major mechanisms: (1) vasospasm, (2) platelet plug formation, and (3) the procoagulant system. While inherited or acquired disorders of all three mechanisms can cause clinically abnormal bleeding, this chapter reviews the molecular basis of the more commonly inherited disorders of the procoagulant system (e.g., hemophilia A and B, and von Willebrand disease) associated with abnormal bleeding.

KW - Bleeding disorder

KW - Coagulation

KW - Diagnostic testing

KW - F2 gene

KW - F5 gene

KW - F8 gene

KW - F9 gene

KW - Factor IX deficiency

KW - Factor V leiden

KW - Factor VIII deficiency

KW - Hemophilia A

KW - Hemophilia B

KW - Homocystinuria

KW - Hyperhomocysteinemia

KW - Molecular testing

KW - Prothrombin

KW - Purpura fulminans neonatalis

KW - Thrombophilia

KW - Venous thrombosis

KW - Von willebrand disease

KW - VWF gene

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SN - 9783319196732

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EP - 223

BT - Molecular Pathology in Clinical Practice

PB - Springer International Publishing

ER -

Coagulation disorders

Abstract

Keywords

ASJC Scopus subject areas

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