Coagulation disorders

Rajiv K. Pruthi, John A. Heit

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Reduced to its simplest form, the vascular system is a series of interconnected biologic conduits filled with fluid moving under pressure. This system is subject to injury and must repair itself in order to avoid exsanguination. This latter function is provided by the hemostatic system. Thus, normal hemostasis is a reparative process and consists of three major mechanisms: (1) vasospasm, which is the main mechanism for controlling bleeding after transection/avulsion injuries of large arteries, arterioles, and veins; (2) platelet plug formation; and (3) the procoagulant system. The procoagulant system consists of the mechanisms by which fluid blood is converted into an insoluble hemostatic thrombus. While inherited or acquired disorders of all three mechanisms can cause clinically abnormal bleeding, this chapter reviews the molecular basis of inherited disorders of the procoagulant system (e. g., hemophilia A and B, von Willebrand disease). Inherited vascular and platelet disorders associated with abnormal bleeding are not discussed here.

Original languageEnglish (US)
Title of host publicationMolecular Pathology in Clinical Practice
PublisherSpringer New York
Pages135-150
Number of pages16
ISBN (Print)038733226X, 9780387332260
DOIs
StatePublished - 2007

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Hemostatics
Hemorrhage
Blood Vessels
Blood Platelets
Exsanguination
Hemophilia B
von Willebrand Diseases
Wounds and Injuries
Hemophilia A
Arterioles
Hemostasis
Veins
Thrombosis
Arteries
Pressure

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Pruthi, R. K., & Heit, J. A. (2007). Coagulation disorders. In Molecular Pathology in Clinical Practice (pp. 135-150). Springer New York. https://doi.org/10.1007/978-0-387-33227-7_12

Coagulation disorders. / Pruthi, Rajiv K.; Heit, John A.

Molecular Pathology in Clinical Practice. Springer New York, 2007. p. 135-150.

Research output: Chapter in Book/Report/Conference proceedingChapter

Pruthi, RK & Heit, JA 2007, Coagulation disorders. in Molecular Pathology in Clinical Practice. Springer New York, pp. 135-150. https://doi.org/10.1007/978-0-387-33227-7_12
Pruthi RK, Heit JA. Coagulation disorders. In Molecular Pathology in Clinical Practice. Springer New York. 2007. p. 135-150 https://doi.org/10.1007/978-0-387-33227-7_12
Pruthi, Rajiv K. ; Heit, John A. / Coagulation disorders. Molecular Pathology in Clinical Practice. Springer New York, 2007. pp. 135-150
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