Coadministration of HIV vaccine vectors with vaccinia viruses expressing IL-15 but not IL-2 induces long-lasting cellular immunity

SangKon Oh, Jay A. Berzofsky, Donald S. Burke, Thomas A. Waldmann, Liyanage P. Perera

Research output: Contribution to journalArticle

142 Citations (Scopus)

Abstract

Vaccine efficacy is determined largely by cellular and humoral immunity as well as long-lasting immunological memory. IL-2 and IL-15 were evaluated in vaccinia vectors expressing HIV gp160 for the establishment of an effective vaccine strategy. Both IL-2 and IL-15 in the vaccinia vector induced strong and long-lasting antibody-mediated immunity as well as a short-term cytotoxic T cell response against HIV gp120. In addition, IL-15 also supported robust CD8+ T cell-mediated long-term immunity, whereas the CD8+ T cell-mediated immunity induced by IL-2 was short-lived. Moreover, we found that the cytokine milieu at the time of priming had surprisingly persistent effects on the character of the memory CD8 T cells long afterward with respect to their fate, functional activities, cytokine receptor expression, and antigen-independent proliferation.

Original languageEnglish (US)
Pages (from-to)3392-3397
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume100
Issue number6
DOIs
StatePublished - Mar 18 2003
Externally publishedYes

Fingerprint

Interleukin-15
AIDS Vaccines
Vaccinia virus
Cellular Immunity
Interleukin-2
T-Lymphocytes
Vaccinia
HIV Envelope Protein gp160
Immunity
Vaccines
HIV Envelope Protein gp120
Immunologic Memory
Cytokine Receptors
Humoral Immunity
Cytokines
Antigens
Antibodies

ASJC Scopus subject areas

  • General

Cite this

Coadministration of HIV vaccine vectors with vaccinia viruses expressing IL-15 but not IL-2 induces long-lasting cellular immunity. / Oh, SangKon; Berzofsky, Jay A.; Burke, Donald S.; Waldmann, Thomas A.; Perera, Liyanage P.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, No. 6, 18.03.2003, p. 3392-3397.

Research output: Contribution to journalArticle

@article{44fa83e2622947be8cbbc69dbb618f32,
title = "Coadministration of HIV vaccine vectors with vaccinia viruses expressing IL-15 but not IL-2 induces long-lasting cellular immunity",
abstract = "Vaccine efficacy is determined largely by cellular and humoral immunity as well as long-lasting immunological memory. IL-2 and IL-15 were evaluated in vaccinia vectors expressing HIV gp160 for the establishment of an effective vaccine strategy. Both IL-2 and IL-15 in the vaccinia vector induced strong and long-lasting antibody-mediated immunity as well as a short-term cytotoxic T cell response against HIV gp120. In addition, IL-15 also supported robust CD8+ T cell-mediated long-term immunity, whereas the CD8+ T cell-mediated immunity induced by IL-2 was short-lived. Moreover, we found that the cytokine milieu at the time of priming had surprisingly persistent effects on the character of the memory CD8 T cells long afterward with respect to their fate, functional activities, cytokine receptor expression, and antigen-independent proliferation.",
author = "SangKon Oh and Berzofsky, {Jay A.} and Burke, {Donald S.} and Waldmann, {Thomas A.} and Perera, {Liyanage P.}",
year = "2003",
month = "3",
day = "18",
doi = "10.1073/pnas.0630592100",
language = "English (US)",
volume = "100",
pages = "3392--3397",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
number = "6",

}

TY - JOUR

T1 - Coadministration of HIV vaccine vectors with vaccinia viruses expressing IL-15 but not IL-2 induces long-lasting cellular immunity

AU - Oh, SangKon

AU - Berzofsky, Jay A.

AU - Burke, Donald S.

AU - Waldmann, Thomas A.

AU - Perera, Liyanage P.

PY - 2003/3/18

Y1 - 2003/3/18

N2 - Vaccine efficacy is determined largely by cellular and humoral immunity as well as long-lasting immunological memory. IL-2 and IL-15 were evaluated in vaccinia vectors expressing HIV gp160 for the establishment of an effective vaccine strategy. Both IL-2 and IL-15 in the vaccinia vector induced strong and long-lasting antibody-mediated immunity as well as a short-term cytotoxic T cell response against HIV gp120. In addition, IL-15 also supported robust CD8+ T cell-mediated long-term immunity, whereas the CD8+ T cell-mediated immunity induced by IL-2 was short-lived. Moreover, we found that the cytokine milieu at the time of priming had surprisingly persistent effects on the character of the memory CD8 T cells long afterward with respect to their fate, functional activities, cytokine receptor expression, and antigen-independent proliferation.

AB - Vaccine efficacy is determined largely by cellular and humoral immunity as well as long-lasting immunological memory. IL-2 and IL-15 were evaluated in vaccinia vectors expressing HIV gp160 for the establishment of an effective vaccine strategy. Both IL-2 and IL-15 in the vaccinia vector induced strong and long-lasting antibody-mediated immunity as well as a short-term cytotoxic T cell response against HIV gp120. In addition, IL-15 also supported robust CD8+ T cell-mediated long-term immunity, whereas the CD8+ T cell-mediated immunity induced by IL-2 was short-lived. Moreover, we found that the cytokine milieu at the time of priming had surprisingly persistent effects on the character of the memory CD8 T cells long afterward with respect to their fate, functional activities, cytokine receptor expression, and antigen-independent proliferation.

UR - http://www.scopus.com/inward/record.url?scp=0037452885&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037452885&partnerID=8YFLogxK

U2 - 10.1073/pnas.0630592100

DO - 10.1073/pnas.0630592100

M3 - Article

C2 - 12626740

AN - SCOPUS:0037452885

VL - 100

SP - 3392

EP - 3397

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 6

ER -