Co-localization of tau and α-synuclein in the olfactory bulb in Alzheimer's disease with amygdala Lewy bodies

Hiroshige Fujishiro, Yoshio Tsuboi, Wen Lang Lin, Hirotake Uchikado, Dennis W Dickson

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

We recently reported that Alzheimer's disease (AD) with amygdala Lewy bodies (ALB) is a distinct form of α-synucleinopathy that occurs in advanced AD. In AD/ALB the α-synuclein pathology correlated with tau pathology, but not amyloid plaques, and there was often co-localization of tau and α-synuclein in the same neuron. Given the anatomical connectivity of the anterior olfactory nucleus and the amygdala, which receives axonal projections from the olfactory bulb, we hypothesized that there might be a relationship between tau and α-synuclein pathology in the olfactory bulb and the amygdala in AD. We screened for α-synuclein pathology in the olfactory bulb in AD with and without ALB, and investigated its relationship with tau pathology. In 38 of 41 (93%) AD/ALB cases and 4 of 21 (19%) AD cases without ALB (AD/non-ALB), α-synuclein pathology was detected in the olfactory bulb. Double immunolabeling at the light and electron microscopic levels revealed co-localization of tau and α-synuclein in the olfactory bulb neurons and neurites. The severity of tau pathology correlated with α-synuclein pathology in the olfactory bulb. In addition, α-synuclein pathology in the olfactory bulb correlated with α-synuclein pathology in amygdala. Tau pathology was greater in both the olfactory bulb and amygdala in AD/ALB than in AD/non-ALB, but there was no difference in tau pathology between the two groups in other brain regions assessed. The present study shows that in AD/ALB, the olfactory bulb is nearly equally vulnerable to tau and α-synuclein pathology as the amygdala and suggests that neurodegeneration in these two anatomical regions is linked.

Original languageEnglish (US)
Pages (from-to)17-24
Number of pages8
JournalActa Neuropathologica
Volume116
Issue number1
DOIs
StatePublished - Jul 2008

Fingerprint

Synucleins
Lewy Bodies
Olfactory Bulb
Amygdala
Alzheimer Disease
Pathology
Neurons
Lewy Body Disease
Amyloid Plaques
Neurites

Keywords

  • α-synuclein
  • Alzheimer's disease
  • Amygdala
  • Olfactory bulb
  • Tau

ASJC Scopus subject areas

  • Clinical Neurology
  • Pathology and Forensic Medicine
  • Neuroscience(all)

Cite this

Co-localization of tau and α-synuclein in the olfactory bulb in Alzheimer's disease with amygdala Lewy bodies. / Fujishiro, Hiroshige; Tsuboi, Yoshio; Lin, Wen Lang; Uchikado, Hirotake; Dickson, Dennis W.

In: Acta Neuropathologica, Vol. 116, No. 1, 07.2008, p. 17-24.

Research output: Contribution to journalArticle

Fujishiro, Hiroshige ; Tsuboi, Yoshio ; Lin, Wen Lang ; Uchikado, Hirotake ; Dickson, Dennis W. / Co-localization of tau and α-synuclein in the olfactory bulb in Alzheimer's disease with amygdala Lewy bodies. In: Acta Neuropathologica. 2008 ; Vol. 116, No. 1. pp. 17-24.
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