CMV DNA detection in dried blood spots for diagnosing congenital CMV infection in Japan

Yoshiaki Yamagishi; Hiromi Miyagawa; Kazuko Wada; Sayuri Matsumoto; Hitomi Arahori; Arihiro Tamura; Hidetoshi Taniguchi; Takahisa Kanekiyo; Junji Sashihara; Tomoko Yoda; Mikiya Kitagawa; Keiichi Ozono

doi:10.1002/jmv.20642

CMV DNA detection in dried blood spots for diagnosing congenital CMV infection in Japan

Yoshiaki Yamagishi, Hiromi Miyagawa, Kazuko Wada, Sayuri Matsumoto, Hitomi Arahori, Arihiro Tamura, Hidetoshi Taniguchi, Takahisa Kanekiyo, Junji Sashihara, Tomoko Yoda, Mikiya Kitagawa, Keiichi Ozono

Neuroscience

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Human cytomegalovirus (CMV) is a leading congenital infectious agent in developed countries. In the past, the incidence of congenital infection has been rather low in Japan because a high seroprevalence of CMV present in young women. However, this seroprevalence has been decreasing in recent years, so that the incidence of congenital CMV infection in Japanese neonates may increase and approach the level seen in other developed countries. The method was used for detecting CMV DNA reported by Barbi et al. [Barbi et al. (1996): Clin Diagn Virol 6:27-32] using a dried blood spot on filter paper, to diagnose congenital CMV infection in Japanese neonates. This method is effective and less laborious than virus isolation both for epidemiological studies and for identifying asymptomatic infected babies. Japanese neonates (1,176) were examined; two of who were asymptomatic were found to be infected.

Original language	English (US)
Pages (from-to)	923-925
Number of pages	3
Journal	Journal of medical virology
Volume	78
Issue number	7
DOIs	https://doi.org/10.1002/jmv.20642
State	Published - Jul 2006

Keywords

Congenital cytomegarovirus infection
Dried blood spot-asymptomatic infection

ASJC Scopus subject areas

Virology
Infectious Diseases

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CMV DNA detection in dried blood spots for diagnosing congenital CMV infection in Japan. / Yamagishi, Yoshiaki; Miyagawa, Hiromi; Wada, Kazuko; Matsumoto, Sayuri; Arahori, Hitomi; Tamura, Arihiro; Taniguchi, Hidetoshi; Kanekiyo, Takahisa; Sashihara, Junji; Yoda, Tomoko; Kitagawa, Mikiya; Ozono, Keiichi.

In: Journal of medical virology, Vol. 78, No. 7, 07.2006, p. 923-925.

Research output: Contribution to journal › Article › peer-review

Yamagishi, Yoshiaki ; Miyagawa, Hiromi ; Wada, Kazuko ; Matsumoto, Sayuri ; Arahori, Hitomi ; Tamura, Arihiro ; Taniguchi, Hidetoshi ; Kanekiyo, Takahisa ; Sashihara, Junji ; Yoda, Tomoko ; Kitagawa, Mikiya ; Ozono, Keiichi. / CMV DNA detection in dried blood spots for diagnosing congenital CMV infection in Japan. In: Journal of medical virology. 2006 ; Vol. 78, No. 7. pp. 923-925.

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abstract = "Human cytomegalovirus (CMV) is a leading congenital infectious agent in developed countries. In the past, the incidence of congenital infection has been rather low in Japan because a high seroprevalence of CMV present in young women. However, this seroprevalence has been decreasing in recent years, so that the incidence of congenital CMV infection in Japanese neonates may increase and approach the level seen in other developed countries. The method was used for detecting CMV DNA reported by Barbi et al. [Barbi et al. (1996): Clin Diagn Virol 6:27-32] using a dried blood spot on filter paper, to diagnose congenital CMV infection in Japanese neonates. This method is effective and less laborious than virus isolation both for epidemiological studies and for identifying asymptomatic infected babies. Japanese neonates (1,176) were examined; two of who were asymptomatic were found to be infected.",

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AU - Wada, Kazuko

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AU - Arahori, Hitomi

AU - Tamura, Arihiro

AU - Taniguchi, Hidetoshi

AU - Kanekiyo, Takahisa

AU - Sashihara, Junji

AU - Yoda, Tomoko

AU - Kitagawa, Mikiya

AU - Ozono, Keiichi

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