Clustering of Parkinson disease: Shared cause of coincidence?

Ajit Kumar, Susan M. Calne, Michael Schulzer, Edwin Mak, Zbigniew K Wszolek, Chris Van Netten, Joseph K C Tsui, A. Jon Stoessl, Donald B. Calne

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background: The spatial and temporal pattern of excessive disease occurrence, termed clustering, may provide clues about the underlying etiology. Objective: To report the occurrence of 3 clusters of Parkinson disease (PD) in Canada. Design and Patients: We determined the population groups containing the clusters, geographical limits, and duration of exposure to the specific environments. We tested whether there was an excessive presence of Parkinson disease by calculating the probability of the observed cases occurring under the null hypothesis that the disease developed independently and at random in cluster subjects. Results of genetic testing for mutations in the α-synuclein, parkin, tau genes, and spinocerebellar ataxia genes (SCA2 and SCA3) were negative. Results: The probabilities of random occurrence (P values) in the 3 clusters were P=7.9 × 10-7 for cluster 1, P=2.6 × 10-7 for cluster 2, and P=1.5 × 10-7 for cluster 3. Conclusions: Our findings indicate an important role for environmental causation in Parkinson disease. A possible role exists for environmental factors such as viral infection and toxins in the light of current evidence.

Original languageEnglish (US)
Pages (from-to)1057-1060
Number of pages4
JournalArchives of Neurology
Volume61
Issue number7
DOIs
StatePublished - Jul 2004

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Cluster Analysis
Parkinson Disease
Synucleins
Spinocerebellar Ataxias
Genetic Testing
Virus Diseases
Population Groups
Causality
Genes
Canada
Mutation
Causes
Parkinson's Disease
Coincidence
Parkinson disease 3

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Kumar, A., Calne, S. M., Schulzer, M., Mak, E., Wszolek, Z. K., Van Netten, C., ... Calne, D. B. (2004). Clustering of Parkinson disease: Shared cause of coincidence? Archives of Neurology, 61(7), 1057-1060. https://doi.org/10.1001/archneur.61.7.1057

Clustering of Parkinson disease : Shared cause of coincidence? / Kumar, Ajit; Calne, Susan M.; Schulzer, Michael; Mak, Edwin; Wszolek, Zbigniew K; Van Netten, Chris; Tsui, Joseph K C; Jon Stoessl, A.; Calne, Donald B.

In: Archives of Neurology, Vol. 61, No. 7, 07.2004, p. 1057-1060.

Research output: Contribution to journalArticle

Kumar, A, Calne, SM, Schulzer, M, Mak, E, Wszolek, ZK, Van Netten, C, Tsui, JKC, Jon Stoessl, A & Calne, DB 2004, 'Clustering of Parkinson disease: Shared cause of coincidence?', Archives of Neurology, vol. 61, no. 7, pp. 1057-1060. https://doi.org/10.1001/archneur.61.7.1057
Kumar, Ajit ; Calne, Susan M. ; Schulzer, Michael ; Mak, Edwin ; Wszolek, Zbigniew K ; Van Netten, Chris ; Tsui, Joseph K C ; Jon Stoessl, A. ; Calne, Donald B. / Clustering of Parkinson disease : Shared cause of coincidence?. In: Archives of Neurology. 2004 ; Vol. 61, No. 7. pp. 1057-1060.
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