@article{b58028cb140844518703c1dbaa2eaf08,
title = "Clusterin ameliorates tau pathology in vivo by inhibiting fibril formation",
abstract = "The molecular chaperone Clusterin (CLU) impacts the amyloid pathway in Alzheimer{\textquoteright}s disease (AD) but its role in tau pathology is unknown. We observed CLU co-localization with tau aggregates in AD and primary tauopathies and CLU levels were upregulated in response to tau accumulation. To further elucidate the effect of CLU on tau pathology, we utilized a gene delivery approach in CLU knock-out (CLU KO) mice to drive expression of tau bearing the P301L mutation. We found that loss of CLU was associated with exacerbated tau pathology and anxiety-like behaviors in our mouse model of tauopathy. Additionally, we found that CLU dramatically inhibited tau fibrilization using an in vitro assay. Together, these results demonstrate that CLU plays a major role in both amyloid and tau pathologies in AD.",
keywords = "Alzheimer{\textquoteright}s disease, Clusterin, Tau, Tauopathy",
author = "Wojtas, {Aleksandra M.} and Yari Carlomagno and Sens, {Jonathon P.} and Kang, {Silvia S.} and Jensen, {Tanner D.} and Aishe Kurti and Baker, {Kelsey E.} and Berry, {Taylor J.} and Phillips, {Virginia R.} and Castanedes, {Monica Casey} and Ayesha Awan and Michael DeTure and {De Castro}, {Cristhoper H.Fernandez} and Librero, {Ariston L.} and Mei Yue and Lillian Daughrity and Jansen-West, {Karen R.} and Cook, {Casey N.} and Dickson, {Dennis W.} and Leonard Petrucelli and Fryer, {John D.}",
note = "Funding Information: J.D.F. was supported by the Mayo Foundation, the Mayo Clinic Center for Individualized Medicine, a Mayo Clinic Gerstner Family Career Development Award, the Ed and Ethel Moore Alzheimer{\textquoteright}s Disease Research Program of Florida Department of Health (6AZ06), the Gilmer Family Foundation, Alzheimer{\textquoteright}s Association NIRP-12-25928, The Rotary Coins for Alzheimer{\textquoteright}s Research Trust Fund, CureAlz Foundation, Ben-Dov Family Foundation, and NIH Grants NS084974, AG062556, AG062110, NS094137, AG057997, AG062077, NS110435, AG047327, and AG049992. Publisher Copyright: {\textcopyright} 2020, The Author(s).",
year = "2020",
month = dec,
doi = "10.1186/s40478-020-01079-1",
language = "English (US)",
volume = "8",
journal = "Acta neuropathologica communications",
issn = "2051-5960",
publisher = "BioMed Central",
number = "1",
}