Abstract
Clostridium difficile is a spore-forming toxigenic bacterium that causes diarrhea and colitis, typically after the use of broad-spectrum antibiotics. The clinical presentation ranges from self-limited diarrhea to fulminant colitis and toxic megacolon. The incidence of this disease is increasing, resulting in major medical and economic consequences. Although most cases respond quickly to medical treatment, C difficile colitis may be serious, especially if diagnosis and treatment are delayed. Recurrent disease represents a particularly challenging problem. Prevention is best accomplished by limiting the use of broad-spectrum antibiotics and following good hygienic techniques and universal precautions to limit the transmission of bacteria. A high index of suspicion results in early diagnosis and treatment and potentially reduces the incidence of complications.
Original language | English (US) |
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Article number | 65003 |
Pages (from-to) | 725-730 |
Number of pages | 6 |
Journal | Mayo Clinic proceedings |
Volume | 76 |
Issue number | 7 |
DOIs | |
State | Published - 2001 |
ASJC Scopus subject areas
- General Medicine