Clostridium difficile - Associated diarrhea and colitis

S. F. Yassin, T. M. Young-Fadok, N. N. Zein, D. S. Pardi

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Clostridium difficile is a spore-forming toxigenic bacterium that causes diarrhea and colitis, typically after the use of broad-spectrum antibiotics. The clinical presentation ranges from self-limited diarrhea to fulminant colitis and toxic megacolon. The incidence of this disease is increasing, resulting in major medical and economic consequences. Although most cases respond quickly to medical treatment, C difficile colitis may be serious, especially if diagnosis and treatment are delayed. Recurrent disease represents a particularly challenging problem. Prevention is best accomplished by limiting the use of broad-spectrum antibiotics and following good hygienic techniques and universal precautions to limit the transmission of bacteria. A high index of suspicion results in early diagnosis and treatment and potentially reduces the incidence of complications.

Original languageEnglish (US)
Pages (from-to)725-730
Number of pages6
JournalMayo Clinic Proceedings
Volume76
Issue number7
StatePublished - 2001

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Clostridium difficile
Colitis
Diarrhea
Toxic Megacolon
Universal Precautions
Anti-Bacterial Agents
Bacteria
Medical Economics
Delayed Diagnosis
Incidence
Spores
Early Diagnosis
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Yassin, S. F., Young-Fadok, T. M., Zein, N. N., & Pardi, D. S. (2001). Clostridium difficile - Associated diarrhea and colitis. Mayo Clinic Proceedings, 76(7), 725-730.

Clostridium difficile - Associated diarrhea and colitis. / Yassin, S. F.; Young-Fadok, T. M.; Zein, N. N.; Pardi, D. S.

In: Mayo Clinic Proceedings, Vol. 76, No. 7, 2001, p. 725-730.

Research output: Contribution to journalArticle

Yassin, SF, Young-Fadok, TM, Zein, NN & Pardi, DS 2001, 'Clostridium difficile - Associated diarrhea and colitis', Mayo Clinic Proceedings, vol. 76, no. 7, pp. 725-730.
Yassin SF, Young-Fadok TM, Zein NN, Pardi DS. Clostridium difficile - Associated diarrhea and colitis. Mayo Clinic Proceedings. 2001;76(7):725-730.
Yassin, S. F. ; Young-Fadok, T. M. ; Zein, N. N. ; Pardi, D. S. / Clostridium difficile - Associated diarrhea and colitis. In: Mayo Clinic Proceedings. 2001 ; Vol. 76, No. 7. pp. 725-730.
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