Closed-loop stimulation of temporal cortex rescues functional networks and improves memory

Youssef Ezzyat, Paul A. Wanda, Deborah F. Levy, Allison Kadel, Ada Aka, Isaac Pedisich, Michael R. Sperling, Ashwini D. Sharan, Bradley C. Lega, Alexis Burks, Robert E. Gross, Cory S. Inman, Barbara C. Jobst, Mark A. Gorenstein, Kathryn A. Davis, Gregory Alan Worrell, Michal T. Kucewicz, Joel M. Stein, Richard Gorniak, Sandhitsu R. DasDaniel S. Rizzuto, Michael J. Kahana

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Memory failures are frustrating and often the result of ineffective encoding. One approach to improving memory outcomes is through direct modulation of brain activity with electrical stimulation. Previous efforts, however, have reported inconsistent effects when using open-loop stimulation and often target the hippocampus and medial temporal lobes. Here we use a closed-loop system to monitor and decode neural activity from direct brain recordings in humans. We apply targeted stimulation to lateral temporal cortex and report that this stimulation rescues periods of poor memory encoding. This system also improves later recall, revealing that the lateral temporal cortex is a reliable target for memory enhancement. Taken together, our results suggest that such systems may provide a therapeutic approach for treating memory dysfunction.

Original languageEnglish (US)
Article number365
JournalNature Communications
Volume9
Issue number1
DOIs
StatePublished - Dec 1 2018

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cortexes
Temporal Lobe
stimulation
Data storage equipment
brain
Brain
coding
hippocampus
feedback control
Closed loop systems
lobes
Electric Stimulation
Hippocampus
recording
Modulation
modulation
augmentation

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Ezzyat, Y., Wanda, P. A., Levy, D. F., Kadel, A., Aka, A., Pedisich, I., ... Kahana, M. J. (2018). Closed-loop stimulation of temporal cortex rescues functional networks and improves memory. Nature Communications, 9(1), [365]. https://doi.org/10.1038/s41467-017-02753-0

Closed-loop stimulation of temporal cortex rescues functional networks and improves memory. / Ezzyat, Youssef; Wanda, Paul A.; Levy, Deborah F.; Kadel, Allison; Aka, Ada; Pedisich, Isaac; Sperling, Michael R.; Sharan, Ashwini D.; Lega, Bradley C.; Burks, Alexis; Gross, Robert E.; Inman, Cory S.; Jobst, Barbara C.; Gorenstein, Mark A.; Davis, Kathryn A.; Worrell, Gregory Alan; Kucewicz, Michal T.; Stein, Joel M.; Gorniak, Richard; Das, Sandhitsu R.; Rizzuto, Daniel S.; Kahana, Michael J.

In: Nature Communications, Vol. 9, No. 1, 365, 01.12.2018.

Research output: Contribution to journalArticle

Ezzyat, Y, Wanda, PA, Levy, DF, Kadel, A, Aka, A, Pedisich, I, Sperling, MR, Sharan, AD, Lega, BC, Burks, A, Gross, RE, Inman, CS, Jobst, BC, Gorenstein, MA, Davis, KA, Worrell, GA, Kucewicz, MT, Stein, JM, Gorniak, R, Das, SR, Rizzuto, DS & Kahana, MJ 2018, 'Closed-loop stimulation of temporal cortex rescues functional networks and improves memory', Nature Communications, vol. 9, no. 1, 365. https://doi.org/10.1038/s41467-017-02753-0
Ezzyat, Youssef ; Wanda, Paul A. ; Levy, Deborah F. ; Kadel, Allison ; Aka, Ada ; Pedisich, Isaac ; Sperling, Michael R. ; Sharan, Ashwini D. ; Lega, Bradley C. ; Burks, Alexis ; Gross, Robert E. ; Inman, Cory S. ; Jobst, Barbara C. ; Gorenstein, Mark A. ; Davis, Kathryn A. ; Worrell, Gregory Alan ; Kucewicz, Michal T. ; Stein, Joel M. ; Gorniak, Richard ; Das, Sandhitsu R. ; Rizzuto, Daniel S. ; Kahana, Michael J. / Closed-loop stimulation of temporal cortex rescues functional networks and improves memory. In: Nature Communications. 2018 ; Vol. 9, No. 1.
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