TY - JOUR
T1 - Closed loop deep brain stimulation
T2 - an evolving technology
AU - Hosain, Md Kamal
AU - Kouzani, Abbas
AU - Tye, Susannah
N1 - Publisher Copyright:
© 2014, Australasian College of Physical Scientists and Engineers in Medicine.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2014/12
Y1 - 2014/12
N2 - Deep brain stimulation is an effective and safe medical treatment for a variety of neurological and psychiatric disorders including Parkinson’s disease, essential tremor, dystonia, and treatment resistant obsessive compulsive disorder. A closed loop deep brain stimulation (CLDBS) system automatically adjusts stimulation parameters by the brain response in real time. The CLDBS continues to evolve due to the advancement in the brain stimulation technologies. This paper provides a study on the existing systems developed for CLDBS. It highlights the issues associated with CLDBS systems including feedback signal recording and processing, stimulation parameters setting, control algorithm, wireless telemetry, size, and power consumption. The benefits and limitations of the existing CLDBS systems are also presented. Whilst robust clinical proof of the benefits of the technology remains to be achieved, it has the potential to offer several advantages over open loop DBS. The CLDBS can improve efficiency and efficacy of therapy, eliminate lengthy start-up period for programming and adjustment, provide a personalized treatment, and make parameters setting automatic and adaptive.
AB - Deep brain stimulation is an effective and safe medical treatment for a variety of neurological and psychiatric disorders including Parkinson’s disease, essential tremor, dystonia, and treatment resistant obsessive compulsive disorder. A closed loop deep brain stimulation (CLDBS) system automatically adjusts stimulation parameters by the brain response in real time. The CLDBS continues to evolve due to the advancement in the brain stimulation technologies. This paper provides a study on the existing systems developed for CLDBS. It highlights the issues associated with CLDBS systems including feedback signal recording and processing, stimulation parameters setting, control algorithm, wireless telemetry, size, and power consumption. The benefits and limitations of the existing CLDBS systems are also presented. Whilst robust clinical proof of the benefits of the technology remains to be achieved, it has the potential to offer several advantages over open loop DBS. The CLDBS can improve efficiency and efficacy of therapy, eliminate lengthy start-up period for programming and adjustment, provide a personalized treatment, and make parameters setting automatic and adaptive.
KW - Automatic stimulation
KW - Biomarker
KW - Closed loop DBS
KW - Deep brain stimulation
KW - Open loop DBS
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U2 - 10.1007/s13246-014-0297-2
DO - 10.1007/s13246-014-0297-2
M3 - Review article
C2 - 25195055
AN - SCOPUS:84921020242
VL - 37
SP - 619
EP - 634
JO - Australasian Physical and Engineering Sciences in Medicine
JF - Australasian Physical and Engineering Sciences in Medicine
SN - 0158-9938
IS - 4
ER -