Close encounters of the RNAi kind

the silencing life of the adherens junctions

Antonis Kourtidis, Panagiotis Z Anastasiadis

Research output: Contribution to journalReview article

Abstract

The adherens junction has been historically considered an essential structural component of epithelial tissues. Although primarily discussed as targets of signaling pathways responsible for cell fate and tissue remodeling, they have also emerged as critical signaling regulators in developmental processes or in disease progression. The recent discovery of a functional localized RNA interference (RNAi) machinery at epithelial adherens junctions revealed a new layer of signaling regulation that is directly associated with the structure itself. This and other findings also indicate that our view of the subcellular localization of RNAi requires revisiting. A number of questions emerge regarding the physiological role and the modes of regulation of the junctional RNAi machinery, pointing towards new directions of investigation.

Original languageEnglish (US)
Pages (from-to)30-36
Number of pages7
JournalCurrent Opinion in Cell Biology
Volume54
DOIs
StatePublished - Oct 1 2018

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Adherens Junctions
RNA Interference
Disease Progression
Epithelium

ASJC Scopus subject areas

  • Cell Biology

Cite this

Close encounters of the RNAi kind : the silencing life of the adherens junctions. / Kourtidis, Antonis; Anastasiadis, Panagiotis Z.

In: Current Opinion in Cell Biology, Vol. 54, 01.10.2018, p. 30-36.

Research output: Contribution to journalReview article

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