Cloning of tumor suppressor genes involved in solid tumor development

David I Smith, M. Del Mar Alonso

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: The homozygous inactivation of tumor suppressor genes is a common event in the multistep process of tumorigenesis. The identification of most tumor suppressor genes known to date has come from the study of individuals with a defective copy of such a gene that increases their predisposition to malignancy. Although much is still to be learned about the function of these genes, they all seem to play a role in cell growth regulation. Karyotypic and molecular studies of several solid tumors suggest the presence of at least three tumor suppressor genes on the short arm of human chromosome 3. We present an overview on the progress made in the identification of tumor suppressor genes involved in solid tumor development. Conclusion: The explosive effort to map the human genome fueled by the Human Genome Project will facilitate the identification of tumor suppressor genes on chromosome 3 and on other chromosomes within the next 2 to 3 years. This information will not only provide a better understanding in cell cycle regulation and differentiation but also new insights in the design of new therapies for the treatment of human cancer.

Original languageEnglish (US)
Pages (from-to)1210-1216
Number of pages7
JournalArchives of Otolaryngology - Head and Neck Surgery
Volume119
Issue number11
StatePublished - 1993
Externally publishedYes

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Tumor Suppressor Genes
Organism Cloning
Chromosomes, Human, Pair 3
Neoplasms
Human Genome Project
Human Chromosomes
Human Genome
Genes
Cell Differentiation
Cell Cycle
Carcinogenesis
Chromosomes
Therapeutics
Growth

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Cloning of tumor suppressor genes involved in solid tumor development. / Smith, David I; Del Mar Alonso, M.

In: Archives of Otolaryngology - Head and Neck Surgery, Vol. 119, No. 11, 1993, p. 1210-1216.

Research output: Contribution to journalArticle

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