TY - JOUR
T1 - Cloning of the human homolog of conductin (AXIN2), a gene mapping to chromosome 17q23-q24
AU - Ming, Mai
AU - Qian, Chiping
AU - Yokomizo, Akira
AU - Smith, David I.
AU - Wanguo, Liu
N1 - Funding Information:
This work was supported by NIH Grant CA48031 (D.I.S.) and by funds from the Mayo Clinic/Foundation (Rochester, MN).
PY - 1999/2/1
Y1 - 1999/2/1
N2 - Conductin or Axil, an Axin homolog, plays an important role in the regulation of β-catenin stability in the Wnt signaling pathway. To facilitate the molecular analysis of the human gene, we isolated the human homolog, AXIN2. The cDNA contains a 2529-bp open reading frame and encodes a putative protein of 843 amino acids. Compared with rat and mouse homologs, AXIN2 shows an overall 89% amino acid identity. Several functional domains in this protein are highly conserved including the GRS (95.9%), GSK-3β (96.3%), Dsh (98%), and β-catenin (89.9%) domains. Radiation hybrid mapping localized the AXIN2 gene to human chromosome 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Human AXIN2 is thus a very strong candidate involved in multiple tumor types.
AB - Conductin or Axil, an Axin homolog, plays an important role in the regulation of β-catenin stability in the Wnt signaling pathway. To facilitate the molecular analysis of the human gene, we isolated the human homolog, AXIN2. The cDNA contains a 2529-bp open reading frame and encodes a putative protein of 843 amino acids. Compared with rat and mouse homologs, AXIN2 shows an overall 89% amino acid identity. Several functional domains in this protein are highly conserved including the GRS (95.9%), GSK-3β (96.3%), Dsh (98%), and β-catenin (89.9%) domains. Radiation hybrid mapping localized the AXIN2 gene to human chromosome 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Human AXIN2 is thus a very strong candidate involved in multiple tumor types.
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U2 - 10.1006/geno.1998.5650
DO - 10.1006/geno.1998.5650
M3 - Article
C2 - 10049590
AN - SCOPUS:0033083827
SN - 0888-7543
VL - 55
SP - 341
EP - 344
JO - Genomics
JF - Genomics
IS - 3
ER -