Abstract
A cDNA encoding a putative bovine intercellular adhesion molecule (ICAM)-3, a ligand of the leukocyte integrin LFA-1 (CD11a/CD18), was sequenced and compared with human ICAM sequences. The 1635-bp bovine sequence codes for a protein of 544 amino acids (aa). This putative bovine ICAM-3 has five immunoglobulin (Ig)-like domains similar to human ICAM-1 and ICAM-3, and belongs to the Ig gene superfamily. The overall identities of the deduced aa sequence with those of human ICAM-3 and ICAM-1 are 61% and 58%, respectively. The predicted number and positions of Cys residues are all conserved between the bovine and human ICAM 3 aa sequences.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 311-313 |
| Number of pages | 3 |
| Journal | Gene |
| Volume | 174 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1996 |
| Externally published | Yes |
Fingerprint
Keywords
- ICAM
- Integrin ligand
- Lymphocyte
- PCR
- Recombinant DNA
ASJC Scopus subject areas
- Genetics
Cite this
Cloning and sequencing of a cDNA encoding bovine intercellular adhesion molecule 3 (ICAM-3). / Lee, Eun Kyung; Kehrli, Marcus E.; Dietz, Allan B; Bosworth, Brad T.; Reinhardt, Timothy A.
In: Gene, Vol. 174, No. 2, 1996, p. 311-313.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cloning and sequencing of a cDNA encoding bovine intercellular adhesion molecule 3 (ICAM-3)
AU - Lee, Eun Kyung
AU - Kehrli, Marcus E.
AU - Dietz, Allan B
AU - Bosworth, Brad T.
AU - Reinhardt, Timothy A.
PY - 1996
Y1 - 1996
N2 - A cDNA encoding a putative bovine intercellular adhesion molecule (ICAM)-3, a ligand of the leukocyte integrin LFA-1 (CD11a/CD18), was sequenced and compared with human ICAM sequences. The 1635-bp bovine sequence codes for a protein of 544 amino acids (aa). This putative bovine ICAM-3 has five immunoglobulin (Ig)-like domains similar to human ICAM-1 and ICAM-3, and belongs to the Ig gene superfamily. The overall identities of the deduced aa sequence with those of human ICAM-3 and ICAM-1 are 61% and 58%, respectively. The predicted number and positions of Cys residues are all conserved between the bovine and human ICAM 3 aa sequences.
AB - A cDNA encoding a putative bovine intercellular adhesion molecule (ICAM)-3, a ligand of the leukocyte integrin LFA-1 (CD11a/CD18), was sequenced and compared with human ICAM sequences. The 1635-bp bovine sequence codes for a protein of 544 amino acids (aa). This putative bovine ICAM-3 has five immunoglobulin (Ig)-like domains similar to human ICAM-1 and ICAM-3, and belongs to the Ig gene superfamily. The overall identities of the deduced aa sequence with those of human ICAM-3 and ICAM-1 are 61% and 58%, respectively. The predicted number and positions of Cys residues are all conserved between the bovine and human ICAM 3 aa sequences.
KW - ICAM
KW - Integrin ligand
KW - Lymphocyte
KW - PCR
KW - Recombinant DNA
UR - http://www.scopus.com/inward/record.url?scp=0029801010&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029801010&partnerID=8YFLogxK
U2 - 10.1016/0378-1119(96)00082-0
DO - 10.1016/0378-1119(96)00082-0
M3 - Article
C2 - 8890753
AN - SCOPUS:0029801010
VL - 174
SP - 311
EP - 313
JO - Gene
JF - Gene
SN - 0378-1119
IS - 2
ER -