Cloning and sequencing of a cDNA encoding bovine intercellular adhesion molecule 3 (ICAM-3)

Eun Kyung Lee; Marcus E. Kehrli; Allan B. Dietz; Brad T. Bosworth; Timothy A. Reinhardt

doi:10.1016/0378-1119(96)00082-0

Cloning and sequencing of a cDNA encoding bovine intercellular adhesion molecule 3 (ICAM-3)

Eun Kyung Lee, Marcus E. Kehrli, Allan B. Dietz, Brad T. Bosworth, Timothy A. Reinhardt

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

A cDNA encoding a putative bovine intercellular adhesion molecule (ICAM)-3, a ligand of the leukocyte integrin LFA-1 (CD11a/CD18), was sequenced and compared with human ICAM sequences. The 1635-bp bovine sequence codes for a protein of 544 amino acids (aa). This putative bovine ICAM-3 has five immunoglobulin (Ig)-like domains similar to human ICAM-1 and ICAM-3, and belongs to the Ig gene superfamily. The overall identities of the deduced aa sequence with those of human ICAM-3 and ICAM-1 are 61% and 58%, respectively. The predicted number and positions of Cys residues are all conserved between the bovine and human ICAM 3 aa sequences.

Original language	English (US)
Pages (from-to)	311-313
Number of pages	3
Journal	Gene
Volume	174
Issue number	2
DOIs	https://doi.org/10.1016/0378-1119(96)00082-0
State	Published - Jan 1 1996

Keywords

ICAM
Integrin ligand
Lymphocyte
PCR
Recombinant DNA

ASJC Scopus subject areas

Genetics

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title = "Cloning and sequencing of a cDNA encoding bovine intercellular adhesion molecule 3 (ICAM-3)",

abstract = "A cDNA encoding a putative bovine intercellular adhesion molecule (ICAM)-3, a ligand of the leukocyte integrin LFA-1 (CD11a/CD18), was sequenced and compared with human ICAM sequences. The 1635-bp bovine sequence codes for a protein of 544 amino acids (aa). This putative bovine ICAM-3 has five immunoglobulin (Ig)-like domains similar to human ICAM-1 and ICAM-3, and belongs to the Ig gene superfamily. The overall identities of the deduced aa sequence with those of human ICAM-3 and ICAM-1 are 61% and 58%, respectively. The predicted number and positions of Cys residues are all conserved between the bovine and human ICAM 3 aa sequences.",

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AU - Lee, Eun Kyung

AU - Kehrli, Marcus E.

AU - Dietz, Allan B.

AU - Bosworth, Brad T.

AU - Reinhardt, Timothy A.

PY - 1996/1/1

Y1 - 1996/1/1

N2 - A cDNA encoding a putative bovine intercellular adhesion molecule (ICAM)-3, a ligand of the leukocyte integrin LFA-1 (CD11a/CD18), was sequenced and compared with human ICAM sequences. The 1635-bp bovine sequence codes for a protein of 544 amino acids (aa). This putative bovine ICAM-3 has five immunoglobulin (Ig)-like domains similar to human ICAM-1 and ICAM-3, and belongs to the Ig gene superfamily. The overall identities of the deduced aa sequence with those of human ICAM-3 and ICAM-1 are 61% and 58%, respectively. The predicted number and positions of Cys residues are all conserved between the bovine and human ICAM 3 aa sequences.

AB - A cDNA encoding a putative bovine intercellular adhesion molecule (ICAM)-3, a ligand of the leukocyte integrin LFA-1 (CD11a/CD18), was sequenced and compared with human ICAM sequences. The 1635-bp bovine sequence codes for a protein of 544 amino acids (aa). This putative bovine ICAM-3 has five immunoglobulin (Ig)-like domains similar to human ICAM-1 and ICAM-3, and belongs to the Ig gene superfamily. The overall identities of the deduced aa sequence with those of human ICAM-3 and ICAM-1 are 61% and 58%, respectively. The predicted number and positions of Cys residues are all conserved between the bovine and human ICAM 3 aa sequences.

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KW - Integrin ligand

KW - Lymphocyte

KW - PCR

KW - Recombinant DNA

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Cloning and sequencing of a cDNA encoding bovine intercellular adhesion molecule 3 (ICAM-3)

Abstract

Keywords

ASJC Scopus subject areas

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