Cloning and sequencing of a cDNA encoding bovine intercellular adhesion molecule 3 (ICAM-3)

Eun Kyung Lee, Marcus E. Kehrli, Allan B. Dietz, Brad T. Bosworth, Timothy A. Reinhardt

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

A cDNA encoding a putative bovine intercellular adhesion molecule (ICAM)-3, a ligand of the leukocyte integrin LFA-1 (CD11a/CD18), was sequenced and compared with human ICAM sequences. The 1635-bp bovine sequence codes for a protein of 544 amino acids (aa). This putative bovine ICAM-3 has five immunoglobulin (Ig)-like domains similar to human ICAM-1 and ICAM-3, and belongs to the Ig gene superfamily. The overall identities of the deduced aa sequence with those of human ICAM-3 and ICAM-1 are 61% and 58%, respectively. The predicted number and positions of Cys residues are all conserved between the bovine and human ICAM 3 aa sequences.

Original languageEnglish (US)
Pages (from-to)311-313
Number of pages3
JournalGene
Volume174
Issue number2
DOIs
StatePublished - Jan 1 1996

Keywords

  • ICAM
  • Integrin ligand
  • Lymphocyte
  • PCR
  • Recombinant DNA

ASJC Scopus subject areas

  • Genetics

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