Abstract
A cDNA encoding a putative bovine intercellular adhesion molecule (ICAM)-3, a ligand of the leukocyte integrin LFA-1 (CD11a/CD18), was sequenced and compared with human ICAM sequences. The 1635-bp bovine sequence codes for a protein of 544 amino acids (aa). This putative bovine ICAM-3 has five immunoglobulin (Ig)-like domains similar to human ICAM-1 and ICAM-3, and belongs to the Ig gene superfamily. The overall identities of the deduced aa sequence with those of human ICAM-3 and ICAM-1 are 61% and 58%, respectively. The predicted number and positions of Cys residues are all conserved between the bovine and human ICAM 3 aa sequences.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 311-313 |
| Number of pages | 3 |
| Journal | Gene |
| Volume | 174 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 1 1996 |
Keywords
- ICAM
- Integrin ligand
- Lymphocyte
- PCR
- Recombinant DNA
ASJC Scopus subject areas
- Genetics
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Lee, E. K., Kehrli, M. E., Dietz, A. B., Bosworth, B. T., & Reinhardt, T. A. (1996). Cloning and sequencing of a cDNA encoding bovine intercellular adhesion molecule 3 (ICAM-3). Gene, 174(2), 311-313. https://doi.org/10.1016/0378-1119(96)00082-0