Cloning and expression analysis of a novel WD repeat gene, WDR3, mapping to 1p12-p13

Jaime O. Claudio; Choong Chin Liew; Jun Ma; Henry H.Q. Heng; A. Keith Stewart; Robert G. Hawley

doi:10.1006/geno.1999.5858

Cloning and expression analysis of a novel WD repeat gene, WDR3, mapping to 1p12-p13

Jaime O. Claudio, Choong Chin Liew, Jun Ma, Henry H.Q. Heng, A. Keith Stewart, Robert G. Hawley

Hematology/Oncology

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

WD repeat proteins are components of multiprotein complexes that are involved in a wide spectrum of cellular activities, such as cell cycle progression, signal transduction, apoptosis, and gene regulation. These proteins are characterized by repeat units bracketed by Gly-His and Trp-Asp (GH-WD). We report here the isolation of a new member of the WD repeat gene family, WDR3, which encodes a putative 943-amino-acid nuclear protein consisting of 10 WD repeat modules. WDR3 is widely expressed in hematopoietic cell lines and in nonhematopoietic tissues. Fluorescence in situ hybridization mapped WDR3 to human chromosome 1p12-p13, a region that is affected by chromosomal rearrangements in a number of hematologic malignancies and solid tumors.

Original language	English (US)
Pages (from-to)	85-89
Number of pages	5
Journal	Genomics
Volume	59
Issue number	1
DOIs	https://doi.org/10.1006/geno.1999.5858
State	Published - Jul 1 1999

ASJC Scopus subject areas

Genetics

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10.1006/geno.1999.5858

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title = "Cloning and expression analysis of a novel WD repeat gene, WDR3, mapping to 1p12-p13",

abstract = "WD repeat proteins are components of multiprotein complexes that are involved in a wide spectrum of cellular activities, such as cell cycle progression, signal transduction, apoptosis, and gene regulation. These proteins are characterized by repeat units bracketed by Gly-His and Trp-Asp (GH-WD). We report here the isolation of a new member of the WD repeat gene family, WDR3, which encodes a putative 943-amino-acid nuclear protein consisting of 10 WD repeat modules. WDR3 is widely expressed in hematopoietic cell lines and in nonhematopoietic tissues. Fluorescence in situ hybridization mapped WDR3 to human chromosome 1p12-p13, a region that is affected by chromosomal rearrangements in a number of hematologic malignancies and solid tumors.",

author = "Claudio, {Jaime O.} and Liew, {Choong Chin} and Jun Ma and Heng, {Henry H.Q.} and Stewart, {A. Keith} and Hawley, {Robert G.}",

note = "Funding Information: We thank Teresa Hawley, Xiao-Yan Wen, and Naihui Huang for providing useful reagents. This work was supported in part by the National Cancer Institute of Canada with funds from the Canadian Cancer Society (R.G.H.) and by the Canadian Genome Analysis and Technology Program (C.C.L.). J.O.C. is supported by a Career Development Award from the Canadian Blood Services and is a recipient of The Edward Christie Stevens Fellowship from the Faculty of Medicine, University of Toronto.",

year = "1999",

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doi = "10.1006/geno.1999.5858",

language = "English (US)",

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T1 - Cloning and expression analysis of a novel WD repeat gene, WDR3, mapping to 1p12-p13

AU - Claudio, Jaime O.

AU - Liew, Choong Chin

AU - Ma, Jun

AU - Heng, Henry H.Q.

AU - Stewart, A. Keith

AU - Hawley, Robert G.

N1 - Funding Information: We thank Teresa Hawley, Xiao-Yan Wen, and Naihui Huang for providing useful reagents. This work was supported in part by the National Cancer Institute of Canada with funds from the Canadian Cancer Society (R.G.H.) and by the Canadian Genome Analysis and Technology Program (C.C.L.). J.O.C. is supported by a Career Development Award from the Canadian Blood Services and is a recipient of The Edward Christie Stevens Fellowship from the Faculty of Medicine, University of Toronto.

PY - 1999/7/1

Y1 - 1999/7/1

N2 - WD repeat proteins are components of multiprotein complexes that are involved in a wide spectrum of cellular activities, such as cell cycle progression, signal transduction, apoptosis, and gene regulation. These proteins are characterized by repeat units bracketed by Gly-His and Trp-Asp (GH-WD). We report here the isolation of a new member of the WD repeat gene family, WDR3, which encodes a putative 943-amino-acid nuclear protein consisting of 10 WD repeat modules. WDR3 is widely expressed in hematopoietic cell lines and in nonhematopoietic tissues. Fluorescence in situ hybridization mapped WDR3 to human chromosome 1p12-p13, a region that is affected by chromosomal rearrangements in a number of hematologic malignancies and solid tumors.

AB - WD repeat proteins are components of multiprotein complexes that are involved in a wide spectrum of cellular activities, such as cell cycle progression, signal transduction, apoptosis, and gene regulation. These proteins are characterized by repeat units bracketed by Gly-His and Trp-Asp (GH-WD). We report here the isolation of a new member of the WD repeat gene family, WDR3, which encodes a putative 943-amino-acid nuclear protein consisting of 10 WD repeat modules. WDR3 is widely expressed in hematopoietic cell lines and in nonhematopoietic tissues. Fluorescence in situ hybridization mapped WDR3 to human chromosome 1p12-p13, a region that is affected by chromosomal rearrangements in a number of hematologic malignancies and solid tumors.

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Cloning and expression analysis of a novel WD repeat gene, WDR3, mapping to 1p12-p13

Abstract

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