Cloning and characterization of the CDZFP gene which encodes a putative zinc finger protein

Wenwen Tang, Jian Yuan, Xinya Chen, Yuxi Shan, Kuntian Luo, Zekun Guo, Yue Zhang, Bo Wan, Long Yu

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

We report here the cloning and characterization of a novel human cytoplasm-distribution zinc finger protein (CDZFP) gene, isolated from human ovary cDNA library, and mapped to 4p12 by searching the UCSC genomic database. The CDZFP cDNA is 1793 base pairs in length and contains an open reading frame (ORF) encoding 236 amino acids. The CDZFP gene consists of 7 exons and encodes a putative zinc finger protein with a transmembrane region and two zinc finger motifs. Subcellular localization demonstrated that CDZFP protein was located in the cytoplasm when overexpressed in Hela cells and northern blot analysis revealed that CDZFP was ubiquitously expressed in 16 human tissues.

Original languageEnglish (US)
Pages (from-to)391-396
Number of pages6
JournalDNA Sequence - Journal of DNA Sequencing and Mapping
Volume16
Issue number5
DOIs
StatePublished - Oct 1 2005

Keywords

  • CDZFP
  • DNA binding
  • Northern blot
  • Subcellular localization

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Endocrinology

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