Clonal rearrangement for immunoglobulin and T-cell receptor genes in systemic Castleman's disease. Association with Epstein-Barr virus

C. A. Hanson, G. Frizzera, D. F. Patton, B. A. Peterson, K. McClain, K. J. Gajl-Peczalska, J. H. Kersey

Research output: Contribution to journalArticle

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Abstract

Castleman's disease is a morphologically and clinically heterogeneous lymphoproliferative disorder. Both a localized benign variant and an aggressive form with systemic manifestations have been described. To investigate the differences between these variants of Castleman's disease, the authors analyzed lymph node DNA from 4 patients with the localized type and 4 with the systemic type of Castleman's disease for immunoglobulin and T-cell receptor gene rearrangements. The role of Epstein-Barr virus (EBV) and cytomegalovirus (CMV) was also studied by viral genomic DNA probes. They detected clonal rearrangements in 3 of the 4 patients with the systemic variant of Castleman's; no patients with localized disease had rearrangements. Copies of EBV genome were also detected in 2 of the 3 patients with clonal rearrangements. These results suggest that systemic Castleman's disease is a disorder distinct from the classical localized variant in that is may evolve into a clonal lymphoproliferation.

Original languageEnglish (US)
Pages (from-to)84-91
Number of pages8
JournalAmerican Journal of Pathology
Volume131
Issue number1
StatePublished - 1988
Externally publishedYes

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Giant Lymph Node Hyperplasia
T-Cell Receptor Genes
Human Herpesvirus 4
Immunoglobulins
T-Lymphocyte Gene Rearrangement
Lymphoproliferative Disorders
DNA Probes
Viral DNA
Cytomegalovirus
Lymph Nodes
Genome
DNA

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Hanson, C. A., Frizzera, G., Patton, D. F., Peterson, B. A., McClain, K., Gajl-Peczalska, K. J., & Kersey, J. H. (1988). Clonal rearrangement for immunoglobulin and T-cell receptor genes in systemic Castleman's disease. Association with Epstein-Barr virus. American Journal of Pathology, 131(1), 84-91.

Clonal rearrangement for immunoglobulin and T-cell receptor genes in systemic Castleman's disease. Association with Epstein-Barr virus. / Hanson, C. A.; Frizzera, G.; Patton, D. F.; Peterson, B. A.; McClain, K.; Gajl-Peczalska, K. J.; Kersey, J. H.

In: American Journal of Pathology, Vol. 131, No. 1, 1988, p. 84-91.

Research output: Contribution to journalArticle

Hanson, CA, Frizzera, G, Patton, DF, Peterson, BA, McClain, K, Gajl-Peczalska, KJ & Kersey, JH 1988, 'Clonal rearrangement for immunoglobulin and T-cell receptor genes in systemic Castleman's disease. Association with Epstein-Barr virus', American Journal of Pathology, vol. 131, no. 1, pp. 84-91.
Hanson, C. A. ; Frizzera, G. ; Patton, D. F. ; Peterson, B. A. ; McClain, K. ; Gajl-Peczalska, K. J. ; Kersey, J. H. / Clonal rearrangement for immunoglobulin and T-cell receptor genes in systemic Castleman's disease. Association with Epstein-Barr virus. In: American Journal of Pathology. 1988 ; Vol. 131, No. 1. pp. 84-91.
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AU - Hanson, C. A.

AU - Frizzera, G.

AU - Patton, D. F.

AU - Peterson, B. A.

AU - McClain, K.

AU - Gajl-Peczalska, K. J.

AU - Kersey, J. H.

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AB - Castleman's disease is a morphologically and clinically heterogeneous lymphoproliferative disorder. Both a localized benign variant and an aggressive form with systemic manifestations have been described. To investigate the differences between these variants of Castleman's disease, the authors analyzed lymph node DNA from 4 patients with the localized type and 4 with the systemic type of Castleman's disease for immunoglobulin and T-cell receptor gene rearrangements. The role of Epstein-Barr virus (EBV) and cytomegalovirus (CMV) was also studied by viral genomic DNA probes. They detected clonal rearrangements in 3 of the 4 patients with the systemic variant of Castleman's; no patients with localized disease had rearrangements. Copies of EBV genome were also detected in 2 of the 3 patients with clonal rearrangements. These results suggest that systemic Castleman's disease is a disorder distinct from the classical localized variant in that is may evolve into a clonal lymphoproliferation.

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