Clonal changes in inflammatory pseudotumor of the lung: A case report

C. S. Snyder, M. Dell'Aquila, P. Haghighi, R. N. Baergen, Kyung Suh Yae Kyung Suh, E. S. Yi

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

Background. Pulmonary inflammatory pseudotumor, also known as plasma cell granuloma among many other names, is widely believed to be an inflammatory or reactive lesion rather than a neoplasm, although its pathogenesis is still controversial. Methods. Cytogenetic analysis was performed on a lung mass that showed typical clinical and pathologic features of inflammatory pseudotumor. Ultrastructural and immunohistochemical studies were performed in addition to routine histologic examination. Results. Cytogenetic study of the lesion revealed clonal anomalies of t(1;2)(q21;p23) and del(4)(q27). The patient, a 30-year-old woman, presented with an asymptomatic but enlarging right lower lobe mass for which partial right lower lobectomy was performed. The lung mass was well circumscribed radiographically and grossly. Microscopically, it was characterized by a loosely arranged spindle cell proliferation with prominent plasma cell infiltration. Fibroblastic and myofibroblastic differentiation of the spindle cells was demonstrated by ultrastructural and immunohistochemical studies. Conclusion. To the authors' knowledge, this is the first report of clonal cytogenetic changes in a clinically and pathologically typical case of inflammatory pseudotumor in the lung. This finding suggests that pulmonary inflammatory pseudotumor might be a true neoplasm rather than a purely inflammatory or reactive lesion.

Original languageEnglish (US)
Pages (from-to)1545-1549
Number of pages5
JournalCancer
Volume76
Issue number9
DOIs
StatePublished - 1995
Externally publishedYes

Fingerprint

Pulmonary Plasma Cell Granuloma
Plasma Cell Granuloma
Cytogenetics
Lung
Cytogenetic Analysis
Plasma Cells
Names
Cell Differentiation
Neoplasms
Cell Proliferation

Keywords

  • cytogenetics
  • fibrosarcoma
  • inflammatory pseudotumor
  • pathogenesis
  • plasma cell granuloma
  • pulmonary
  • translocation

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Snyder, C. S., Dell'Aquila, M., Haghighi, P., Baergen, R. N., Yae Kyung Suh, K. S., & Yi, E. S. (1995). Clonal changes in inflammatory pseudotumor of the lung: A case report. Cancer, 76(9), 1545-1549. https://doi.org/10.1002/1097-0142(19951101)76:9<1545::AID-CNCR2820760908>3.0.CO;2-H

Clonal changes in inflammatory pseudotumor of the lung : A case report. / Snyder, C. S.; Dell'Aquila, M.; Haghighi, P.; Baergen, R. N.; Yae Kyung Suh, Kyung Suh; Yi, E. S.

In: Cancer, Vol. 76, No. 9, 1995, p. 1545-1549.

Research output: Contribution to journalArticle

Snyder, CS, Dell'Aquila, M, Haghighi, P, Baergen, RN, Yae Kyung Suh, KS & Yi, ES 1995, 'Clonal changes in inflammatory pseudotumor of the lung: A case report', Cancer, vol. 76, no. 9, pp. 1545-1549. https://doi.org/10.1002/1097-0142(19951101)76:9<1545::AID-CNCR2820760908>3.0.CO;2-H
Snyder, C. S. ; Dell'Aquila, M. ; Haghighi, P. ; Baergen, R. N. ; Yae Kyung Suh, Kyung Suh ; Yi, E. S. / Clonal changes in inflammatory pseudotumor of the lung : A case report. In: Cancer. 1995 ; Vol. 76, No. 9. pp. 1545-1549.
@article{c3631ed7f32f4d47ba6299ce9b3ca30b,
title = "Clonal changes in inflammatory pseudotumor of the lung: A case report",
abstract = "Background. Pulmonary inflammatory pseudotumor, also known as plasma cell granuloma among many other names, is widely believed to be an inflammatory or reactive lesion rather than a neoplasm, although its pathogenesis is still controversial. Methods. Cytogenetic analysis was performed on a lung mass that showed typical clinical and pathologic features of inflammatory pseudotumor. Ultrastructural and immunohistochemical studies were performed in addition to routine histologic examination. Results. Cytogenetic study of the lesion revealed clonal anomalies of t(1;2)(q21;p23) and del(4)(q27). The patient, a 30-year-old woman, presented with an asymptomatic but enlarging right lower lobe mass for which partial right lower lobectomy was performed. The lung mass was well circumscribed radiographically and grossly. Microscopically, it was characterized by a loosely arranged spindle cell proliferation with prominent plasma cell infiltration. Fibroblastic and myofibroblastic differentiation of the spindle cells was demonstrated by ultrastructural and immunohistochemical studies. Conclusion. To the authors' knowledge, this is the first report of clonal cytogenetic changes in a clinically and pathologically typical case of inflammatory pseudotumor in the lung. This finding suggests that pulmonary inflammatory pseudotumor might be a true neoplasm rather than a purely inflammatory or reactive lesion.",
keywords = "cytogenetics, fibrosarcoma, inflammatory pseudotumor, pathogenesis, plasma cell granuloma, pulmonary, translocation",
author = "Snyder, {C. S.} and M. Dell'Aquila and P. Haghighi and Baergen, {R. N.} and {Yae Kyung Suh}, {Kyung Suh} and Yi, {E. S.}",
year = "1995",
doi = "10.1002/1097-0142(19951101)76:9<1545::AID-CNCR2820760908>3.0.CO;2-H",
language = "English (US)",
volume = "76",
pages = "1545--1549",
journal = "Cancer",
issn = "0008-543X",
publisher = "John Wiley and Sons Inc.",
number = "9",

}

TY - JOUR

T1 - Clonal changes in inflammatory pseudotumor of the lung

T2 - A case report

AU - Snyder, C. S.

AU - Dell'Aquila, M.

AU - Haghighi, P.

AU - Baergen, R. N.

AU - Yae Kyung Suh, Kyung Suh

AU - Yi, E. S.

PY - 1995

Y1 - 1995

N2 - Background. Pulmonary inflammatory pseudotumor, also known as plasma cell granuloma among many other names, is widely believed to be an inflammatory or reactive lesion rather than a neoplasm, although its pathogenesis is still controversial. Methods. Cytogenetic analysis was performed on a lung mass that showed typical clinical and pathologic features of inflammatory pseudotumor. Ultrastructural and immunohistochemical studies were performed in addition to routine histologic examination. Results. Cytogenetic study of the lesion revealed clonal anomalies of t(1;2)(q21;p23) and del(4)(q27). The patient, a 30-year-old woman, presented with an asymptomatic but enlarging right lower lobe mass for which partial right lower lobectomy was performed. The lung mass was well circumscribed radiographically and grossly. Microscopically, it was characterized by a loosely arranged spindle cell proliferation with prominent plasma cell infiltration. Fibroblastic and myofibroblastic differentiation of the spindle cells was demonstrated by ultrastructural and immunohistochemical studies. Conclusion. To the authors' knowledge, this is the first report of clonal cytogenetic changes in a clinically and pathologically typical case of inflammatory pseudotumor in the lung. This finding suggests that pulmonary inflammatory pseudotumor might be a true neoplasm rather than a purely inflammatory or reactive lesion.

AB - Background. Pulmonary inflammatory pseudotumor, also known as plasma cell granuloma among many other names, is widely believed to be an inflammatory or reactive lesion rather than a neoplasm, although its pathogenesis is still controversial. Methods. Cytogenetic analysis was performed on a lung mass that showed typical clinical and pathologic features of inflammatory pseudotumor. Ultrastructural and immunohistochemical studies were performed in addition to routine histologic examination. Results. Cytogenetic study of the lesion revealed clonal anomalies of t(1;2)(q21;p23) and del(4)(q27). The patient, a 30-year-old woman, presented with an asymptomatic but enlarging right lower lobe mass for which partial right lower lobectomy was performed. The lung mass was well circumscribed radiographically and grossly. Microscopically, it was characterized by a loosely arranged spindle cell proliferation with prominent plasma cell infiltration. Fibroblastic and myofibroblastic differentiation of the spindle cells was demonstrated by ultrastructural and immunohistochemical studies. Conclusion. To the authors' knowledge, this is the first report of clonal cytogenetic changes in a clinically and pathologically typical case of inflammatory pseudotumor in the lung. This finding suggests that pulmonary inflammatory pseudotumor might be a true neoplasm rather than a purely inflammatory or reactive lesion.

KW - cytogenetics

KW - fibrosarcoma

KW - inflammatory pseudotumor

KW - pathogenesis

KW - plasma cell granuloma

KW - pulmonary

KW - translocation

UR - http://www.scopus.com/inward/record.url?scp=0028874674&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028874674&partnerID=8YFLogxK

U2 - 10.1002/1097-0142(19951101)76:9<1545::AID-CNCR2820760908>3.0.CO;2-H

DO - 10.1002/1097-0142(19951101)76:9<1545::AID-CNCR2820760908>3.0.CO;2-H

M3 - Article

C2 - 8635056

AN - SCOPUS:0028874674

VL - 76

SP - 1545

EP - 1549

JO - Cancer

JF - Cancer

SN - 0008-543X

IS - 9

ER -