Clomiphene citrate as a new treatment for SUNCT: Hormonal manipulation for hypothalamic-influenced trigeminal autonomic cephalalgias

Todd D. Rozen, Joel R. Saper, Fred D. Sheftell, David W. Dodick

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

We present a patient with treatment refractory short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) who was found to have low levels of serum testosterone supporting the hypothalamic connection to this trigeminal autonomic cephalalgia. Clomiphene citrate therapy induced a significant elevation of testosterone levels (by its effect on hypothalamic estrogen receptors) and led to a dramatic reduction in SUNCT attacks. Hormonal manipulation may be a treatment strategy for hypothalamic-influenced trigeminal autonomic cephalalgias.

Original languageEnglish (US)
Pages (from-to)754-756
Number of pages3
JournalHeadache
Volume45
Issue number6
DOIs
StatePublished - Jun 1 2005

Keywords

  • Clomiphene citrate
  • Hypothalamus
  • SUNCT
  • Testosterone
  • Trigeminal autonomic cephalalgias

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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