Clomiphene citrate as a new treatment for SUNCT: Hormonal manipulation for hypothalamic-influenced trigeminal autonomic cephalalgias

Todd D. Rozen; Joel R. Saper; Fred D. Sheftell; David W. Dodick

doi:10.1111/j.1526-4610.2005.05143_2.x

Clomiphene citrate as a new treatment for SUNCT: Hormonal manipulation for hypothalamic-influenced trigeminal autonomic cephalalgias

Todd D. Rozen, Joel R. Saper, Fred D. Sheftell, David W. Dodick

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

We present a patient with treatment refractory short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) who was found to have low levels of serum testosterone supporting the hypothalamic connection to this trigeminal autonomic cephalalgia. Clomiphene citrate therapy induced a significant elevation of testosterone levels (by its effect on hypothalamic estrogen receptors) and led to a dramatic reduction in SUNCT attacks. Hormonal manipulation may be a treatment strategy for hypothalamic-influenced trigeminal autonomic cephalalgias.

Original language	English (US)
Pages (from-to)	754-756
Number of pages	3
Journal	Headache
Volume	45
Issue number	6
DOIs	https://doi.org/10.1111/j.1526-4610.2005.05143_2.x
State	Published - Jun 2005

Keywords

Clomiphene citrate
Hypothalamus
SUNCT
Testosterone
Trigeminal autonomic cephalalgias

ASJC Scopus subject areas

Neurology
Clinical Neurology

Access to Document

10.1111/j.1526-4610.2005.05143_2.x

Cite this

@article{1e77c0461ada4233924efd0be1d1cecb,

title = "Clomiphene citrate as a new treatment for SUNCT: Hormonal manipulation for hypothalamic-influenced trigeminal autonomic cephalalgias",

abstract = "We present a patient with treatment refractory short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) who was found to have low levels of serum testosterone supporting the hypothalamic connection to this trigeminal autonomic cephalalgia. Clomiphene citrate therapy induced a significant elevation of testosterone levels (by its effect on hypothalamic estrogen receptors) and led to a dramatic reduction in SUNCT attacks. Hormonal manipulation may be a treatment strategy for hypothalamic-influenced trigeminal autonomic cephalalgias.",

keywords = "Clomiphene citrate, Hypothalamus, SUNCT, Testosterone, Trigeminal autonomic cephalalgias",

author = "Rozen, {Todd D.} and Saper, {Joel R.} and Sheftell, {Fred D.} and Dodick, {David W.}",

year = "2005",

month = jun,

doi = "10.1111/j.1526-4610.2005.05143_2.x",

language = "English (US)",

volume = "45",

pages = "754--756",

journal = "Headache",

issn = "0017-8748",

publisher = "Wiley-Blackwell",

number = "6",

}

TY - JOUR

T1 - Clomiphene citrate as a new treatment for SUNCT

T2 - Hormonal manipulation for hypothalamic-influenced trigeminal autonomic cephalalgias

AU - Rozen, Todd D.

AU - Saper, Joel R.

AU - Sheftell, Fred D.

AU - Dodick, David W.

PY - 2005/6

Y1 - 2005/6

N2 - We present a patient with treatment refractory short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) who was found to have low levels of serum testosterone supporting the hypothalamic connection to this trigeminal autonomic cephalalgia. Clomiphene citrate therapy induced a significant elevation of testosterone levels (by its effect on hypothalamic estrogen receptors) and led to a dramatic reduction in SUNCT attacks. Hormonal manipulation may be a treatment strategy for hypothalamic-influenced trigeminal autonomic cephalalgias.

AB - We present a patient with treatment refractory short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) who was found to have low levels of serum testosterone supporting the hypothalamic connection to this trigeminal autonomic cephalalgia. Clomiphene citrate therapy induced a significant elevation of testosterone levels (by its effect on hypothalamic estrogen receptors) and led to a dramatic reduction in SUNCT attacks. Hormonal manipulation may be a treatment strategy for hypothalamic-influenced trigeminal autonomic cephalalgias.

KW - Clomiphene citrate

KW - Hypothalamus

KW - SUNCT

KW - Testosterone

KW - Trigeminal autonomic cephalalgias

UR - http://www.scopus.com/inward/record.url?scp=20444401137&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=20444401137&partnerID=8YFLogxK

U2 - 10.1111/j.1526-4610.2005.05143_2.x

DO - 10.1111/j.1526-4610.2005.05143_2.x

M3 - Article

C2 - 15953310

AN - SCOPUS:20444401137

SN - 0017-8748

VL - 45

SP - 754

EP - 756

JO - Headache

JF - Headache

IS - 6

ER -

Clomiphene citrate as a new treatment for SUNCT: Hormonal manipulation for hypothalamic-influenced trigeminal autonomic cephalalgias

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this