Clinicopathological significance of the expression of PD-L1 in non-small cell lung cancer

M. Angeles Montero, Ozan Aricak, Lorand Kis, Akira Yoshikawa, Luigi De Petris, Oscar Grundberg, Hoa H.N. Pham, Anja C. Roden, Junya Fukuoka, Richard Attanoos, Ricardo Guijarro, Felix Alarcón, Kati Lindström, Cristian Ortiz-Villalón

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: PD1/PD-L1 pathway targeting therapies are nowadays an established treatment option for patients with NSCLC. We assessed whether PD-L1 expression in NSCLC tumor cells was associated with specific clinical features or overall survival using four different clones. Methods and results: A retrospective study included formalin-fixed paraffin embedded (FFPE) surgical tumors from 482 patients. PD-L1 status was assessed with immunohistochemistry in tumor cells on tissue microarrays using clones 28-8, 22C3, SP263 and SP142. Associations with OS were assessed by Kaplan-Meier and multivariate Cox's regression analysis. Patients' median age: 68 years (39–86); histology: adenocarcinoma (AdCa) 61%, squamous-cell carcinoma (SqCC) 33%, and large cell carcinoma (LCC) 6%; p-stage: IA (46%), IB (30%), IIA (10%), IIB (11,4%), IIIA (1,2%), IIIB – IV (0,4%). PD-L1 positivity (≥1%) in NSCLC for clones 28-8, 22C3, SP263, SP142 was 41.5%, 34.2%, 42.7%, 10.4%, respectively (Pearson Chi-square p < 0.0001). PD-L1 expression was correlated with histology, tumor size and grading. Statistically significant association between PD-L1 expression and OS in NSCLC and Non-AdCa was observed with clone SP142 (log-rank p = 0.045 and p = 0.05, respectively). Statistically significant association between PD-L1 expression and OS in LCC was observed with clones 22C3 (log-rank p = 0.009) and SP263 (log-rank p = 0.050). Conclusions: Overexpression of the PD-L1 clone SP142 was associated with poor overall survival in NSCLC and Non-AdCa. Clones 22C3 and SP263 were associated with poor prognosis in LCC. PD-L1 status might serve as a prognostic marker in NSCLC.

Original languageEnglish (US)
Article number151701
JournalAnnals of Diagnostic Pathology
Volume51
DOIs
StatePublished - Apr 2021

Keywords

  • Lung cancer and immunotherapy
  • PD-L1 status in tumor cells
  • Predictive biomarkers in non-small cell lung cancer

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Fingerprint Dive into the research topics of 'Clinicopathological significance of the expression of PD-L1 in non-small cell lung cancer'. Together they form a unique fingerprint.

Cite this