Clinicopathological features and outcomes of fibrolamellar hepatocellular carcinoma

Sakti Chakrabarti, Sri Harsha Tella, Anuhya Kommalapati, Brandon M. Huffman, Siddhartha Yadav, Irbaz Bin Riaz, Gaurav Goyal, Kabir Mody, Mitesh Borad, Sean Cleary, Rory L. Smoot, Amit Mahipal

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Background: Clinicopathological features and the outcomes of patients with fibrolamellar hepatocellular carcinoma (FLHCC) are not clearly defined. Methods: Data were collected by retrospective chart review on 42 patients with FLHCC treated between 1990 and 2017 at Mayo Clinic. Results: Of 42 patients (median age at diagnosis 22 years), 10 patients (23.8%) had stage I disease and 32 patients (76.2%) had stage II to IVB disease. All 10 patients with stage I disease and 21 of 32 patients with stage II-IVB disease underwent resection at presentation. In stage I patient group, 6 patients experienced recurrence with a median time to recurrence of 30.5 months and a 5-year overall survival (OS) of 86%. Patients with stage II to IVB disease who underwent resection (n=21) upfront had a median OS of 32.5 months and 5-year OS of 44%. In the upfront surgery group, 71% of patients experienced recurrence. The median OS of patients with unresectable disease (n=11) was 10 months. Four out of nine patients treated with sorafenib had stable disease and one patient with programmed cell death ligand-1 (PD-L1) expressing tumor had a near complete response after 2 months of therapy with nivolumab. Conclusions: In FLHCC, surgical resection was associated with prolonged OS; although most patients had a disease recurrence regardless of disease stage and resection margin status. The response to kinase inhibitor, sorafenib, was variable. In select cases, therapy with a checkpoint inhibitor may provide a viable treatment option.

Original languageEnglish (US)
Pages (from-to)554-561
Number of pages8
JournalJournal of Gastrointestinal Oncology
Volume10
Issue number3
DOIs
StatePublished - 2019

Keywords

  • Fibrolamellar carcinoma
  • Gemcitabine
  • Nivolumab
  • Sorafenib

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology

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