Clinical utility of dual-energy CT for evaluation of tophaceous gout

Madhura A. Desai, Jeffrey J. Peterson, Hillary Warren Garner, Mark J. Kransdorf

Research output: Contribution to journalArticle

105 Citations (Scopus)

Abstract

Although diagnosing gout generally is straightforward, atypical disease may present a challenge if it is associated with unusual symptoms or sites, discordant serum urate level, or mimics of gout. Dual-energy computed tomography (CT) may be used to differentiate urate crystals from calcium by using specific attenuation characteristics, which may help diagnose gout. In patients with known tophaceous gout, dual-energy CT may be used for serial volumetric quantification of subclinical tophi to evaluate response to treatment. Given the utility of dual-energy CT in challenging cases and its ability to provide an objective outcomes measure in patients with tophaceous gout, dual-energy CT promises to be a unique and clinically relevant modality in the diagnosis and management of gout.

Original languageEnglish (US)
Pages (from-to)1365-1375
Number of pages11
JournalRadiographics
Volume31
Issue number5
DOIs
StatePublished - Sep 2011

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Gout
Tomography
Uric Acid
Outcome Assessment (Health Care)
Calcium
Serum

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Desai, M. A., Peterson, J. J., Garner, H. W., & Kransdorf, M. J. (2011). Clinical utility of dual-energy CT for evaluation of tophaceous gout. Radiographics, 31(5), 1365-1375. https://doi.org/10.1148/rg.315115510

Clinical utility of dual-energy CT for evaluation of tophaceous gout. / Desai, Madhura A.; Peterson, Jeffrey J.; Garner, Hillary Warren; Kransdorf, Mark J.

In: Radiographics, Vol. 31, No. 5, 09.2011, p. 1365-1375.

Research output: Contribution to journalArticle

Desai, MA, Peterson, JJ, Garner, HW & Kransdorf, MJ 2011, 'Clinical utility of dual-energy CT for evaluation of tophaceous gout', Radiographics, vol. 31, no. 5, pp. 1365-1375. https://doi.org/10.1148/rg.315115510
Desai MA, Peterson JJ, Garner HW, Kransdorf MJ. Clinical utility of dual-energy CT for evaluation of tophaceous gout. Radiographics. 2011 Sep;31(5):1365-1375. https://doi.org/10.1148/rg.315115510
Desai, Madhura A. ; Peterson, Jeffrey J. ; Garner, Hillary Warren ; Kransdorf, Mark J. / Clinical utility of dual-energy CT for evaluation of tophaceous gout. In: Radiographics. 2011 ; Vol. 31, No. 5. pp. 1365-1375.
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