Clinical Use of Quantitative Computed Tomography-Based Advanced Techniques in the Management of Osteoporosis in Adults: the 2015 ISCD Official Positions-Part III

Klaus Engelke, Thomas Lang, Sundeep Khosla, Ling Qin, Philippe Zysset, William D. Leslie, John A. Shepherd, John T. Shousboe

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The International Society for Clinical Densitometry (ISCD) has developed new official positions for the clinical use of computed tomography (CT) scans acquired without a calibration phantom, for example, CT scans obtained for other diagnosis such as colonography. This also addresses techniques suggested for opportunistic screening of osteoporosis. The ISCD task force for quantitative CT reviewed the evidence for clinical applications of these new techniques and presented a report with recommendations at the 2015 ISCD Position Development Conference. Here we discuss the agreed upon ISCD official positions with supporting medical evidence, rationale, controversy, and suggestions for further study. Advanced techniques summarized as statistical parameter mapping methods were also reviewed. Their future use is promising but the clinical application is premature. The clinical use of QCT of the hip is addressed in part I and of finite element analysis of the hip and spine in part II.

Original languageEnglish (US)
Pages (from-to)393-407
Number of pages15
JournalJournal of Clinical Densitometry
Issue number3
StatePublished - Jul 1 2015



  • Asynchronous and internal calibration
  • opportunistic screening
  • osteoporosis
  • quantitative computed tomography (QCT)
  • statistical parameter mapping (SPM)

ASJC Scopus subject areas

  • Medicine(all)

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