Clinical use of biochemical markers of bone remodeling

Current status and future directions

A. C. Looker, D. C. Bauer, C. H. Chesnut, C. M. Gundberg, M. C. Hochberg, G. Klee, M. Kleerekoper, N. B. Watts, N. H. Bell

Research output: Contribution to journalArticle

198 Citations (Scopus)

Abstract

Biochemical markers of bone turnover provide a means of evaluating skeletal dynamics that complements static measurements of bone mineral density (BMD). This review evaluates the use of commercially available bone turnover markers as aids in diagnosis and monitoring response to treatment in patients with osteoporosis. High within-person variability complicates but does not preclude their use. Elevated bone resorption markers appear to be associated with increased fracture risk in elderly women, but there is less evidence of a relationship between bone formation markers and fracture risk. The critical question of predicting fracture efficacy with treatment has not been answered. Changes in bone markers as currently determined do not predict BMD response to either bisphosphonates or hormone replacement therapy. Single measurements of markers do not predict BMD cross-sectionally (except possibly in the very elderly), or change in BMD in individual patients, either treated or untreated. On the other hand, research applications of bone turnover markers are of value in investigating the pathogenesis and treatment of bone diseases. Markers have potential in the clinical management of osteoporosis, but their use in this regard is not established. Additional studies with fracture endpoints and information on negative and positive predictive value are needed to evaluate fully the utility of bone turnover markers in individual patients.

Original languageEnglish (US)
Pages (from-to)467-480
Number of pages14
JournalOsteoporosis International
Volume11
Issue number6
DOIs
StatePublished - 2000

Fingerprint

Bone Remodeling
Bone Density
Biomarkers
Osteoporosis
Bone Diseases
Bone Fractures
Hormone Replacement Therapy
Diphosphonates
Bone Resorption
Osteogenesis
Bone and Bones
Direction compound
Therapeutics
Research

Keywords

  • Bone turnover markers
  • Clinical management
  • Osteoporosis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Looker, A. C., Bauer, D. C., Chesnut, C. H., Gundberg, C. M., Hochberg, M. C., Klee, G., ... Bell, N. H. (2000). Clinical use of biochemical markers of bone remodeling: Current status and future directions. Osteoporosis International, 11(6), 467-480. https://doi.org/10.1007/s001980070088

Clinical use of biochemical markers of bone remodeling : Current status and future directions. / Looker, A. C.; Bauer, D. C.; Chesnut, C. H.; Gundberg, C. M.; Hochberg, M. C.; Klee, G.; Kleerekoper, M.; Watts, N. B.; Bell, N. H.

In: Osteoporosis International, Vol. 11, No. 6, 2000, p. 467-480.

Research output: Contribution to journalArticle

Looker, AC, Bauer, DC, Chesnut, CH, Gundberg, CM, Hochberg, MC, Klee, G, Kleerekoper, M, Watts, NB & Bell, NH 2000, 'Clinical use of biochemical markers of bone remodeling: Current status and future directions', Osteoporosis International, vol. 11, no. 6, pp. 467-480. https://doi.org/10.1007/s001980070088
Looker, A. C. ; Bauer, D. C. ; Chesnut, C. H. ; Gundberg, C. M. ; Hochberg, M. C. ; Klee, G. ; Kleerekoper, M. ; Watts, N. B. ; Bell, N. H. / Clinical use of biochemical markers of bone remodeling : Current status and future directions. In: Osteoporosis International. 2000 ; Vol. 11, No. 6. pp. 467-480.
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