Clinical trials of mitotic kinesin inhibitors

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Abnormal mitotic activity underlies the pathology of a number of human diseases, most notably cancer, and has motivated the search for more specific and less toxic inhibitors of the mitotic process. In this chapter, I review the clinical experience with one group of inhibitors that target mitotic kinesins. I will discuss the results of phase I and II trials with these drugs and place the results of these trials in a context to explain how they can be utilized in future human studies.

Original languageEnglish (US)
Title of host publicationKinesins and Cancer
PublisherSense Publishers
Pages63-76
Number of pages14
ISBN (Electronic)9789401797320
ISBN (Print)9789401797313
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Fingerprint

Kinesin
Poisons
Pathology
Clinical Trials
Pharmaceutical Preparations
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Chemistry(all)

Cite this

Clinical trials of mitotic kinesin inhibitors. / Rosenfeld, Steven.

Kinesins and Cancer. Sense Publishers, 2015. p. 63-76.

Research output: Chapter in Book/Report/Conference proceedingChapter

Rosenfeld, Steven. / Clinical trials of mitotic kinesin inhibitors. Kinesins and Cancer. Sense Publishers, 2015. pp. 63-76
@inbook{13015be9decf4ce8baa545575b97dba9,
title = "Clinical trials of mitotic kinesin inhibitors",
abstract = "Abnormal mitotic activity underlies the pathology of a number of human diseases, most notably cancer, and has motivated the search for more specific and less toxic inhibitors of the mitotic process. In this chapter, I review the clinical experience with one group of inhibitors that target mitotic kinesins. I will discuss the results of phase I and II trials with these drugs and place the results of these trials in a context to explain how they can be utilized in future human studies.",
author = "Steven Rosenfeld",
year = "2015",
month = "1",
day = "1",
doi = "10.1007/978-94-017-9732-0_4",
language = "English (US)",
isbn = "9789401797313",
pages = "63--76",
booktitle = "Kinesins and Cancer",
publisher = "Sense Publishers",

}

TY - CHAP

T1 - Clinical trials of mitotic kinesin inhibitors

AU - Rosenfeld, Steven

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Abnormal mitotic activity underlies the pathology of a number of human diseases, most notably cancer, and has motivated the search for more specific and less toxic inhibitors of the mitotic process. In this chapter, I review the clinical experience with one group of inhibitors that target mitotic kinesins. I will discuss the results of phase I and II trials with these drugs and place the results of these trials in a context to explain how they can be utilized in future human studies.

AB - Abnormal mitotic activity underlies the pathology of a number of human diseases, most notably cancer, and has motivated the search for more specific and less toxic inhibitors of the mitotic process. In this chapter, I review the clinical experience with one group of inhibitors that target mitotic kinesins. I will discuss the results of phase I and II trials with these drugs and place the results of these trials in a context to explain how they can be utilized in future human studies.

UR - http://www.scopus.com/inward/record.url?scp=84943173110&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84943173110&partnerID=8YFLogxK

U2 - 10.1007/978-94-017-9732-0_4

DO - 10.1007/978-94-017-9732-0_4

M3 - Chapter

AN - SCOPUS:84943173110

SN - 9789401797313

SP - 63

EP - 76

BT - Kinesins and Cancer

PB - Sense Publishers

ER -