Clinical trials of mitotic kinesin inhibitors

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Abnormal mitotic activity underlies the pathology of a number of human diseases, most notably cancer, and has motivated the search for more specific and less toxic inhibitors of the mitotic process. In this chapter, I review the clinical experience with one group of inhibitors that target mitotic kinesins. I will discuss the results of phase I and II trials with these drugs and place the results of these trials in a context to explain how they can be utilized in future human studies.

Original languageEnglish (US)
Title of host publicationKinesins and Cancer
PublisherSense Publishers
Pages63-76
Number of pages14
ISBN (Electronic)9789401797320
ISBN (Print)9789401797313
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Chemistry(all)

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