TY - JOUR
T1 - Clinical trials for early (pre-dementia) Alzheimer's disease
T2 - A case for mild cognitive impairment
AU - Petersen, R. C.
N1 - Funding Information:
Acknowledgments: Funding for this work is supported by grants from the National Institute on Aging P50 AG16574, U01 AG 06786, U01 AG24904.
PY - 2010
Y1 - 2010
N2 - A goal of many clinical trials for Alzheimer's disease is to develop disease-modifying therapies for the pre-dementia period of the Alzheimer's disease process. However, there are no clinical criteria for characterizing subjects in this range. The construct of amnestic mild cognitive impairment has been extensively investigated and may provide useful clinical criteria for this clinical stage. It is proposed that the clinical criteria for mild cognitive impairment be enriched with imaging and other biomarkers to improve the specificity of the outcome, and these criteria might suffice for pre-dementia clinical trials.
AB - A goal of many clinical trials for Alzheimer's disease is to develop disease-modifying therapies for the pre-dementia period of the Alzheimer's disease process. However, there are no clinical criteria for characterizing subjects in this range. The construct of amnestic mild cognitive impairment has been extensively investigated and may provide useful clinical criteria for this clinical stage. It is proposed that the clinical criteria for mild cognitive impairment be enriched with imaging and other biomarkers to improve the specificity of the outcome, and these criteria might suffice for pre-dementia clinical trials.
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U2 - 10.1007/s12603-010-0068-z
DO - 10.1007/s12603-010-0068-z
M3 - Article
C2 - 20306001
AN - SCOPUS:77951778475
SN - 1279-7707
VL - 14
SP - 304
EP - 305
JO - Journal of Nutrition, Health and Aging
JF - Journal of Nutrition, Health and Aging
IS - 4
ER -