Clinical subtypes of Alzheimer's disease

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Alzheimer's disease (AD) can present as a variety of clinical profiles. Although the most common presentation is that of a progressive amnestic disorder with subsequent involvement of other cognitive functions and personality alterations, there are numerous other clinical profiles. AD can present as a focal cortical degenerative syndrome with the clinical features dependent on the regions of the brain involved. Some of these syndromes include disturbances of language, visuospatial skills, attentional functions, executive processes and praxis. The neuropathological substrate of these disorders is variable and can include AD. Recently, the Lewy body variant of AD has been described. Finally, other modifying features that affect the progression of AD, such as extrapyramidal symptoms and myoclonus, are also discussed. Although the progressive amnestic form of AD is the most common presentation, other variations on the clinical syndrome can be important to identify because they may have implications for prognosis and treatment.

Original languageEnglish (US)
Pages (from-to)16-24
Number of pages9
JournalDementia and Geriatric Cognitive Disorders
Volume9
Issue numberSUPPL. 3
DOIs
StatePublished - Oct 1998

Fingerprint

Alzheimer Disease
Myoclonus
Executive Function
Cognition
Personality
Language
Brain
Therapeutics

Keywords

  • Alzheimer's disease
  • Focal cortical degenerative syndromes
  • Lewy body disease
  • Progressive amnestic syndrome

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Geriatrics and Gerontology

Cite this

Clinical subtypes of Alzheimer's disease. / Petersen, Ronald Carl.

In: Dementia and Geriatric Cognitive Disorders, Vol. 9, No. SUPPL. 3, 10.1998, p. 16-24.

Research output: Contribution to journalArticle

@article{e54a8e89875e41f99730f6c9b2780598,
title = "Clinical subtypes of Alzheimer's disease",
abstract = "Alzheimer's disease (AD) can present as a variety of clinical profiles. Although the most common presentation is that of a progressive amnestic disorder with subsequent involvement of other cognitive functions and personality alterations, there are numerous other clinical profiles. AD can present as a focal cortical degenerative syndrome with the clinical features dependent on the regions of the brain involved. Some of these syndromes include disturbances of language, visuospatial skills, attentional functions, executive processes and praxis. The neuropathological substrate of these disorders is variable and can include AD. Recently, the Lewy body variant of AD has been described. Finally, other modifying features that affect the progression of AD, such as extrapyramidal symptoms and myoclonus, are also discussed. Although the progressive amnestic form of AD is the most common presentation, other variations on the clinical syndrome can be important to identify because they may have implications for prognosis and treatment.",
keywords = "Alzheimer's disease, Focal cortical degenerative syndromes, Lewy body disease, Progressive amnestic syndrome",
author = "Petersen, {Ronald Carl}",
year = "1998",
month = "10",
doi = "10.1159/000051199",
language = "English (US)",
volume = "9",
pages = "16--24",
journal = "Dementia and Geriatric Cognitive Disorders",
issn = "1420-8008",
publisher = "S. Karger AG",
number = "SUPPL. 3",

}

TY - JOUR

T1 - Clinical subtypes of Alzheimer's disease

AU - Petersen, Ronald Carl

PY - 1998/10

Y1 - 1998/10

N2 - Alzheimer's disease (AD) can present as a variety of clinical profiles. Although the most common presentation is that of a progressive amnestic disorder with subsequent involvement of other cognitive functions and personality alterations, there are numerous other clinical profiles. AD can present as a focal cortical degenerative syndrome with the clinical features dependent on the regions of the brain involved. Some of these syndromes include disturbances of language, visuospatial skills, attentional functions, executive processes and praxis. The neuropathological substrate of these disorders is variable and can include AD. Recently, the Lewy body variant of AD has been described. Finally, other modifying features that affect the progression of AD, such as extrapyramidal symptoms and myoclonus, are also discussed. Although the progressive amnestic form of AD is the most common presentation, other variations on the clinical syndrome can be important to identify because they may have implications for prognosis and treatment.

AB - Alzheimer's disease (AD) can present as a variety of clinical profiles. Although the most common presentation is that of a progressive amnestic disorder with subsequent involvement of other cognitive functions and personality alterations, there are numerous other clinical profiles. AD can present as a focal cortical degenerative syndrome with the clinical features dependent on the regions of the brain involved. Some of these syndromes include disturbances of language, visuospatial skills, attentional functions, executive processes and praxis. The neuropathological substrate of these disorders is variable and can include AD. Recently, the Lewy body variant of AD has been described. Finally, other modifying features that affect the progression of AD, such as extrapyramidal symptoms and myoclonus, are also discussed. Although the progressive amnestic form of AD is the most common presentation, other variations on the clinical syndrome can be important to identify because they may have implications for prognosis and treatment.

KW - Alzheimer's disease

KW - Focal cortical degenerative syndromes

KW - Lewy body disease

KW - Progressive amnestic syndrome

UR - http://www.scopus.com/inward/record.url?scp=0031782921&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031782921&partnerID=8YFLogxK

U2 - 10.1159/000051199

DO - 10.1159/000051199

M3 - Article

C2 - 9853198

AN - SCOPUS:0031782921

VL - 9

SP - 16

EP - 24

JO - Dementia and Geriatric Cognitive Disorders

JF - Dementia and Geriatric Cognitive Disorders

SN - 1420-8008

IS - SUPPL. 3

ER -