Clinical staging of chronic rejection in lung transplantation using home spirometry

S. M. Finkelstein, M. I. Hertz, P. Dutta, L. Chlan, C. Wielinski, B. Lindgren, W. J. Warwick, M. Snyder

Research output: Contribution to journalConference article

4 Scopus citations

Abstract

Clinical staging of chronic rejection in transplanted lungs has been evaluated in a group of transplant recipients using a paperless, electronic spirometer/diary instrument for home monitoring. Five of 60 subjects doing home monitoring were diagnosed with chronic rejection. Clinic and home spirometry variables were used in the staging algorithm to determine the onset and rate of clinical decline related to the rejection. Clinic and home FEV1 provided comparable onset and rates of decline; home FEF25%-75% detected onset from 65 - 477 days earlier than either FEV1 measure, and was more sensitive to declining function than FEV1. Detection of chronic rejection can be achieved with the home monitor, and home FEF25%-75% provides a new indicator that should be considered in future staging systems.

Original languageEnglish (US)
Pages (from-to)721-722
Number of pages2
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume17
Issue number1
StatePublished - Dec 1 1995
EventProceedings of the 1995 IEEE Engineering in Medicine and Biology 17th Annual Conference and 21st Canadian Medical and Biological Engineering Conference. Part 2 (of 2) - Montreal, Can
Duration: Sep 20 1995Sep 23 1995

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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    Finkelstein, S. M., Hertz, M. I., Dutta, P., Chlan, L., Wielinski, C., Lindgren, B., Warwick, W. J., & Snyder, M. (1995). Clinical staging of chronic rejection in lung transplantation using home spirometry. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, 17(1), 721-722.