Clinical significance of viral load in the diagnosis of cytomegalovirus disease after liver transplantation

Julio Mendez, Mark Espy, Thomas F. Smith, Jennie Wilson, Russel Wiesner, Carlos V. Paya

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Abstract

In a cohort of 43 liver transplant recipients who did not receive antiviral prophylaxis, qualitative and quantitative polymerase chain reactions (PCRs) from peripheral blood were prospectively compared to determine their value in the diagnosis of established cytomegalovirus (CMV) disease and for the early detection of CMV replication as a marker for preemptive antiviral therapy. Using a cutoff of 7000 copies of CMV DNA per sample, the specificity and positive predictive values of qualitative PCR for the diagnosis of established CMV disease increased from 33% to 89% and from 54% to 82%, respectively, without reducing the 100% sensitivity and negative predictive value. By contrast, quantification of viral load provided no additional advantage to qualitative PCR for the early diagnosis of CMV infection before development of disease.

Original languageEnglish (US)
Pages (from-to)1477-1481
Number of pages5
JournalTransplantation
Volume65
Issue number11
DOIs
StatePublished - Jun 15 1998

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ASJC Scopus subject areas

  • Transplantation

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