Clinical Significance of Persistent Global and Focal Computed Tomography Nephrograms After Cardiac Catheterization and Their Relationships to Urinary Biomarkers of Kidney Damage and Procedural Factors: Pilot Study

Lisa L. Chu, Richard W. Katzberg, Richard Solomon, Jeffrey Southard, Scott J. Evans, Chin Shang Li, Jennifer S McDonald, Catherine Payne, John M. Boone, Satish P. RamachandraRao

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

OBJECTIVES: We evaluate the relationships between persistent computed tomography (CT) nephrograms and acute kidney injury after cardiac catheterization (CC). We compare changes in urinary biomarkers kidney injury molecule 1 (KIM-1), cystatin C, and serum creatinine to procedural factors. MATERIALS AND METHODS: From 159 eligible patients without renal insufficiency (estimated glomerular filtration rate >60 mL/min), 40 random patients (age range, 42–81 years; mean age, 64 years; 25 men, 15 women) gave written informed consent to undergo unenhanced CT limited to their kidneys 24 hours after CC. Semiquantitative assessment for global nephrograms and quantitative assessment of focal nephrograms in each kidney was performed. Computed tomography attenuation (Hounsfield units) of the renal cortex was measured. Serum creatinine, KIM-1, and cystatin C were measured before and 24 hours after CC. RESULTS: Robust linear regression showed that both relative changes in KIM-1 and cystatin C had positive relationships with kidney CT attenuation (P = 0.012 and 0.002, respectively). Spearman rank correlation coefficient showed that both absolute changes and relative changes in KIM-1 and cystatin C had positive correlations with global nephrogram grades (P = 0.025 and 0.040, respectively, for KIM-1; P = 0.013 and 0.019, respectively, for cystatin C). CONCLUSIONS: Global nephrograms on unenhanced CT in patients who have undergone CC are significantly correlated with changes in urinary biomarkers for kidney damage.

Original languageEnglish (US)
JournalInvestigative Radiology
DOIs
StateAccepted/In press - Mar 11 2016

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Cardiac Catheterization
Biomarkers
Tomography
Kidney
Cystatin C
Wounds and Injuries
Creatinine
Nonparametric Statistics
Informed Consent
Serum
Glomerular Filtration Rate
Acute Kidney Injury
Renal Insufficiency
Linear Models

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Clinical Significance of Persistent Global and Focal Computed Tomography Nephrograms After Cardiac Catheterization and Their Relationships to Urinary Biomarkers of Kidney Damage and Procedural Factors : Pilot Study. / Chu, Lisa L.; Katzberg, Richard W.; Solomon, Richard; Southard, Jeffrey; Evans, Scott J.; Li, Chin Shang; McDonald, Jennifer S; Payne, Catherine; Boone, John M.; RamachandraRao, Satish P.

In: Investigative Radiology, 11.03.2016.

Research output: Contribution to journalArticle

Chu, Lisa L. ; Katzberg, Richard W. ; Solomon, Richard ; Southard, Jeffrey ; Evans, Scott J. ; Li, Chin Shang ; McDonald, Jennifer S ; Payne, Catherine ; Boone, John M. ; RamachandraRao, Satish P. / Clinical Significance of Persistent Global and Focal Computed Tomography Nephrograms After Cardiac Catheterization and Their Relationships to Urinary Biomarkers of Kidney Damage and Procedural Factors : Pilot Study. In: Investigative Radiology. 2016.
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abstract = "OBJECTIVES: We evaluate the relationships between persistent computed tomography (CT) nephrograms and acute kidney injury after cardiac catheterization (CC). We compare changes in urinary biomarkers kidney injury molecule 1 (KIM-1), cystatin C, and serum creatinine to procedural factors. MATERIALS AND METHODS: From 159 eligible patients without renal insufficiency (estimated glomerular filtration rate >60 mL/min), 40 random patients (age range, 42–81 years; mean age, 64 years; 25 men, 15 women) gave written informed consent to undergo unenhanced CT limited to their kidneys 24 hours after CC. Semiquantitative assessment for global nephrograms and quantitative assessment of focal nephrograms in each kidney was performed. Computed tomography attenuation (Hounsfield units) of the renal cortex was measured. Serum creatinine, KIM-1, and cystatin C were measured before and 24 hours after CC. RESULTS: Robust linear regression showed that both relative changes in KIM-1 and cystatin C had positive relationships with kidney CT attenuation (P = 0.012 and 0.002, respectively). Spearman rank correlation coefficient showed that both absolute changes and relative changes in KIM-1 and cystatin C had positive correlations with global nephrogram grades (P = 0.025 and 0.040, respectively, for KIM-1; P = 0.013 and 0.019, respectively, for cystatin C). CONCLUSIONS: Global nephrograms on unenhanced CT in patients who have undergone CC are significantly correlated with changes in urinary biomarkers for kidney damage.",
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AU - Solomon, Richard

AU - Southard, Jeffrey

AU - Evans, Scott J.

AU - Li, Chin Shang

AU - McDonald, Jennifer S

AU - Payne, Catherine

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AU - RamachandraRao, Satish P.

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N2 - OBJECTIVES: We evaluate the relationships between persistent computed tomography (CT) nephrograms and acute kidney injury after cardiac catheterization (CC). We compare changes in urinary biomarkers kidney injury molecule 1 (KIM-1), cystatin C, and serum creatinine to procedural factors. MATERIALS AND METHODS: From 159 eligible patients without renal insufficiency (estimated glomerular filtration rate >60 mL/min), 40 random patients (age range, 42–81 years; mean age, 64 years; 25 men, 15 women) gave written informed consent to undergo unenhanced CT limited to their kidneys 24 hours after CC. Semiquantitative assessment for global nephrograms and quantitative assessment of focal nephrograms in each kidney was performed. Computed tomography attenuation (Hounsfield units) of the renal cortex was measured. Serum creatinine, KIM-1, and cystatin C were measured before and 24 hours after CC. RESULTS: Robust linear regression showed that both relative changes in KIM-1 and cystatin C had positive relationships with kidney CT attenuation (P = 0.012 and 0.002, respectively). Spearman rank correlation coefficient showed that both absolute changes and relative changes in KIM-1 and cystatin C had positive correlations with global nephrogram grades (P = 0.025 and 0.040, respectively, for KIM-1; P = 0.013 and 0.019, respectively, for cystatin C). CONCLUSIONS: Global nephrograms on unenhanced CT in patients who have undergone CC are significantly correlated with changes in urinary biomarkers for kidney damage.

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