Clinical significance and outcome of subclinical status epilepticus in adults

Elson L. So, Kevin H. Ruggles, Peter A. Ahmann, Sue K. Trudeau, Karen J. Weatherford, Max R. Trenerry

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

We reviewed the medical records and the EEGs of all adults treated for status epilepticus (SE) in our center in 4 years. EEG detected subclinical SE in almost half (49%) of the 45 consecutive patients identified. Comparing patients with and those without subclinical SE, we noted that patients with subclinical SE were older (p = 0.02) and more likely to have focal brain lesions (p = 0.04). In the absence of focal brain lesions, subclinical SE was still more common in old adults (p < 0.01). Regardless of age, subclinical SE was more difficult to control than clinically overt SE (p = 0.001). Although 24% of all patients died in ≤60 days, late mortality was not associated with subclinical SE (p > 0.05). However, an association between late mortality and presence of focal brain lesions was suggested by a low p-value (0.053). Subclinical SE appeared on the EEG as frequent discrete seizure episodes in all but 3 patients. None of the patients had a progressive sequence of EEG patterns, as was reported in the literature. Initiation of treatment before EEG recording in most of our patients (82%) might have interrupted the sequential appearance of the EEG patterns.

Original languageEnglish (US)
Pages (from-to)11-15
Number of pages5
JournalJournal of Epilepsy
Volume8
Issue number1
DOIs
StatePublished - 1995

Fingerprint

Status Epilepticus
Electroencephalography
Brain
Medical Records
Seizures
Mortality

Keywords

  • Electroencephalogram
  • Electrographic seizure
  • Epilepsy
  • Status epilepticus
  • Subclinical seizure

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

So, E. L., Ruggles, K. H., Ahmann, P. A., Trudeau, S. K., Weatherford, K. J., & Trenerry, M. R. (1995). Clinical significance and outcome of subclinical status epilepticus in adults. Journal of Epilepsy, 8(1), 11-15. https://doi.org/10.1016/0896-6974(94)00003-I

Clinical significance and outcome of subclinical status epilepticus in adults. / So, Elson L.; Ruggles, Kevin H.; Ahmann, Peter A.; Trudeau, Sue K.; Weatherford, Karen J.; Trenerry, Max R.

In: Journal of Epilepsy, Vol. 8, No. 1, 1995, p. 11-15.

Research output: Contribution to journalArticle

So, EL, Ruggles, KH, Ahmann, PA, Trudeau, SK, Weatherford, KJ & Trenerry, MR 1995, 'Clinical significance and outcome of subclinical status epilepticus in adults', Journal of Epilepsy, vol. 8, no. 1, pp. 11-15. https://doi.org/10.1016/0896-6974(94)00003-I
So, Elson L. ; Ruggles, Kevin H. ; Ahmann, Peter A. ; Trudeau, Sue K. ; Weatherford, Karen J. ; Trenerry, Max R. / Clinical significance and outcome of subclinical status epilepticus in adults. In: Journal of Epilepsy. 1995 ; Vol. 8, No. 1. pp. 11-15.
@article{560fd36a2f824176a24a94523d087f6e,
title = "Clinical significance and outcome of subclinical status epilepticus in adults",
abstract = "We reviewed the medical records and the EEGs of all adults treated for status epilepticus (SE) in our center in 4 years. EEG detected subclinical SE in almost half (49{\%}) of the 45 consecutive patients identified. Comparing patients with and those without subclinical SE, we noted that patients with subclinical SE were older (p = 0.02) and more likely to have focal brain lesions (p = 0.04). In the absence of focal brain lesions, subclinical SE was still more common in old adults (p < 0.01). Regardless of age, subclinical SE was more difficult to control than clinically overt SE (p = 0.001). Although 24{\%} of all patients died in ≤60 days, late mortality was not associated with subclinical SE (p > 0.05). However, an association between late mortality and presence of focal brain lesions was suggested by a low p-value (0.053). Subclinical SE appeared on the EEG as frequent discrete seizure episodes in all but 3 patients. None of the patients had a progressive sequence of EEG patterns, as was reported in the literature. Initiation of treatment before EEG recording in most of our patients (82{\%}) might have interrupted the sequential appearance of the EEG patterns.",
keywords = "Electroencephalogram, Electrographic seizure, Epilepsy, Status epilepticus, Subclinical seizure",
author = "So, {Elson L.} and Ruggles, {Kevin H.} and Ahmann, {Peter A.} and Trudeau, {Sue K.} and Weatherford, {Karen J.} and Trenerry, {Max R.}",
year = "1995",
doi = "10.1016/0896-6974(94)00003-I",
language = "English (US)",
volume = "8",
pages = "11--15",
journal = "Epilepsy Research",
issn = "0920-1211",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Clinical significance and outcome of subclinical status epilepticus in adults

AU - So, Elson L.

AU - Ruggles, Kevin H.

AU - Ahmann, Peter A.

AU - Trudeau, Sue K.

AU - Weatherford, Karen J.

AU - Trenerry, Max R.

PY - 1995

Y1 - 1995

N2 - We reviewed the medical records and the EEGs of all adults treated for status epilepticus (SE) in our center in 4 years. EEG detected subclinical SE in almost half (49%) of the 45 consecutive patients identified. Comparing patients with and those without subclinical SE, we noted that patients with subclinical SE were older (p = 0.02) and more likely to have focal brain lesions (p = 0.04). In the absence of focal brain lesions, subclinical SE was still more common in old adults (p < 0.01). Regardless of age, subclinical SE was more difficult to control than clinically overt SE (p = 0.001). Although 24% of all patients died in ≤60 days, late mortality was not associated with subclinical SE (p > 0.05). However, an association between late mortality and presence of focal brain lesions was suggested by a low p-value (0.053). Subclinical SE appeared on the EEG as frequent discrete seizure episodes in all but 3 patients. None of the patients had a progressive sequence of EEG patterns, as was reported in the literature. Initiation of treatment before EEG recording in most of our patients (82%) might have interrupted the sequential appearance of the EEG patterns.

AB - We reviewed the medical records and the EEGs of all adults treated for status epilepticus (SE) in our center in 4 years. EEG detected subclinical SE in almost half (49%) of the 45 consecutive patients identified. Comparing patients with and those without subclinical SE, we noted that patients with subclinical SE were older (p = 0.02) and more likely to have focal brain lesions (p = 0.04). In the absence of focal brain lesions, subclinical SE was still more common in old adults (p < 0.01). Regardless of age, subclinical SE was more difficult to control than clinically overt SE (p = 0.001). Although 24% of all patients died in ≤60 days, late mortality was not associated with subclinical SE (p > 0.05). However, an association between late mortality and presence of focal brain lesions was suggested by a low p-value (0.053). Subclinical SE appeared on the EEG as frequent discrete seizure episodes in all but 3 patients. None of the patients had a progressive sequence of EEG patterns, as was reported in the literature. Initiation of treatment before EEG recording in most of our patients (82%) might have interrupted the sequential appearance of the EEG patterns.

KW - Electroencephalogram

KW - Electrographic seizure

KW - Epilepsy

KW - Status epilepticus

KW - Subclinical seizure

UR - http://www.scopus.com/inward/record.url?scp=0028950938&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028950938&partnerID=8YFLogxK

U2 - 10.1016/0896-6974(94)00003-I

DO - 10.1016/0896-6974(94)00003-I

M3 - Article

AN - SCOPUS:0028950938

VL - 8

SP - 11

EP - 15

JO - Epilepsy Research

JF - Epilepsy Research

SN - 0920-1211

IS - 1

ER -