Clinical signifacance of granuloma in Crohn's disease

Nizar N. Ramzan, Jonathan A Leighton, Russell I. Heigh, Michael S. Shapiro

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Crohn's disease (CD) is diagnosed from information obtained clinically, pathologically, and radiologically. One important pathologic finding is a granuloma, which is helpful when a positive diagnosis of CD will affect treatment. Whether the presence of a granuloma has any clinical implication is not clear. We conducted a retrospective study to determine whether a granuloma found on a biopsy sample is associated with disease severity, fistulizing or perianal disease, frequent relapses, and extraintestinal manifestations. Eighty-two patients were identified who had a biopsy or bowel resection for CD between 1990 and 1994 at a tertiary referral center; 21 (25.6%) had a granuloma. This group was compared with a group of 61 patients without a granuloma. Forty-five percent were male (n = 37), mean age at diagnosis was 42.6 years (median, 39.5 years), mean disease duration at presentation was 8.8 years (median, 4.8 years), and mean follow-up duration was 2 years (range, 1 day to 10.2 years). No significant differences were demonstrated between the two groups by the Fisher exact test with regard to fistulizing or perianal disease, oral aphthous ulcers, disease severity, axial or peripheral arthralgia, episcleritis, anterior uveitis, erythema nodosum, or pyoderma gangrenosum.

Original languageEnglish (US)
Pages (from-to)168-173
Number of pages6
JournalInflammatory Bowel Diseases
Volume8
Issue number3
StatePublished - 2002

Fingerprint

Granuloma
Crohn Disease
Scleritis
Oral Ulcer
Pyoderma Gangrenosum
Aphthous Stomatitis
Anterior Uveitis
Biopsy
Erythema Nodosum
Arthralgia
Tertiary Care Centers
Retrospective Studies
Recurrence
Therapeutics

Keywords

  • Clinical significance
  • Crohn's disease
  • Granuloma

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Ramzan, N. N., Leighton, J. A., Heigh, R. I., & Shapiro, M. S. (2002). Clinical signifacance of granuloma in Crohn's disease. Inflammatory Bowel Diseases, 8(3), 168-173.

Clinical signifacance of granuloma in Crohn's disease. / Ramzan, Nizar N.; Leighton, Jonathan A; Heigh, Russell I.; Shapiro, Michael S.

In: Inflammatory Bowel Diseases, Vol. 8, No. 3, 2002, p. 168-173.

Research output: Contribution to journalArticle

Ramzan, NN, Leighton, JA, Heigh, RI & Shapiro, MS 2002, 'Clinical signifacance of granuloma in Crohn's disease', Inflammatory Bowel Diseases, vol. 8, no. 3, pp. 168-173.
Ramzan, Nizar N. ; Leighton, Jonathan A ; Heigh, Russell I. ; Shapiro, Michael S. / Clinical signifacance of granuloma in Crohn's disease. In: Inflammatory Bowel Diseases. 2002 ; Vol. 8, No. 3. pp. 168-173.
@article{11bb0d8781434f52ae16299217d19028,
title = "Clinical signifacance of granuloma in Crohn's disease",
abstract = "Crohn's disease (CD) is diagnosed from information obtained clinically, pathologically, and radiologically. One important pathologic finding is a granuloma, which is helpful when a positive diagnosis of CD will affect treatment. Whether the presence of a granuloma has any clinical implication is not clear. We conducted a retrospective study to determine whether a granuloma found on a biopsy sample is associated with disease severity, fistulizing or perianal disease, frequent relapses, and extraintestinal manifestations. Eighty-two patients were identified who had a biopsy or bowel resection for CD between 1990 and 1994 at a tertiary referral center; 21 (25.6{\%}) had a granuloma. This group was compared with a group of 61 patients without a granuloma. Forty-five percent were male (n = 37), mean age at diagnosis was 42.6 years (median, 39.5 years), mean disease duration at presentation was 8.8 years (median, 4.8 years), and mean follow-up duration was 2 years (range, 1 day to 10.2 years). No significant differences were demonstrated between the two groups by the Fisher exact test with regard to fistulizing or perianal disease, oral aphthous ulcers, disease severity, axial or peripheral arthralgia, episcleritis, anterior uveitis, erythema nodosum, or pyoderma gangrenosum.",
keywords = "Clinical significance, Crohn's disease, Granuloma",
author = "Ramzan, {Nizar N.} and Leighton, {Jonathan A} and Heigh, {Russell I.} and Shapiro, {Michael S.}",
year = "2002",
language = "English (US)",
volume = "8",
pages = "168--173",
journal = "Inflammatory Bowel Diseases",
issn = "1078-0998",
publisher = "John Wiley and Sons Inc.",
number = "3",

}

TY - JOUR

T1 - Clinical signifacance of granuloma in Crohn's disease

AU - Ramzan, Nizar N.

AU - Leighton, Jonathan A

AU - Heigh, Russell I.

AU - Shapiro, Michael S.

PY - 2002

Y1 - 2002

N2 - Crohn's disease (CD) is diagnosed from information obtained clinically, pathologically, and radiologically. One important pathologic finding is a granuloma, which is helpful when a positive diagnosis of CD will affect treatment. Whether the presence of a granuloma has any clinical implication is not clear. We conducted a retrospective study to determine whether a granuloma found on a biopsy sample is associated with disease severity, fistulizing or perianal disease, frequent relapses, and extraintestinal manifestations. Eighty-two patients were identified who had a biopsy or bowel resection for CD between 1990 and 1994 at a tertiary referral center; 21 (25.6%) had a granuloma. This group was compared with a group of 61 patients without a granuloma. Forty-five percent were male (n = 37), mean age at diagnosis was 42.6 years (median, 39.5 years), mean disease duration at presentation was 8.8 years (median, 4.8 years), and mean follow-up duration was 2 years (range, 1 day to 10.2 years). No significant differences were demonstrated between the two groups by the Fisher exact test with regard to fistulizing or perianal disease, oral aphthous ulcers, disease severity, axial or peripheral arthralgia, episcleritis, anterior uveitis, erythema nodosum, or pyoderma gangrenosum.

AB - Crohn's disease (CD) is diagnosed from information obtained clinically, pathologically, and radiologically. One important pathologic finding is a granuloma, which is helpful when a positive diagnosis of CD will affect treatment. Whether the presence of a granuloma has any clinical implication is not clear. We conducted a retrospective study to determine whether a granuloma found on a biopsy sample is associated with disease severity, fistulizing or perianal disease, frequent relapses, and extraintestinal manifestations. Eighty-two patients were identified who had a biopsy or bowel resection for CD between 1990 and 1994 at a tertiary referral center; 21 (25.6%) had a granuloma. This group was compared with a group of 61 patients without a granuloma. Forty-five percent were male (n = 37), mean age at diagnosis was 42.6 years (median, 39.5 years), mean disease duration at presentation was 8.8 years (median, 4.8 years), and mean follow-up duration was 2 years (range, 1 day to 10.2 years). No significant differences were demonstrated between the two groups by the Fisher exact test with regard to fistulizing or perianal disease, oral aphthous ulcers, disease severity, axial or peripheral arthralgia, episcleritis, anterior uveitis, erythema nodosum, or pyoderma gangrenosum.

KW - Clinical significance

KW - Crohn's disease

KW - Granuloma

UR - http://www.scopus.com/inward/record.url?scp=0036000334&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036000334&partnerID=8YFLogxK

M3 - Article

C2 - 11979136

AN - SCOPUS:0036000334

VL - 8

SP - 168

EP - 173

JO - Inflammatory Bowel Diseases

JF - Inflammatory Bowel Diseases

SN - 1078-0998

IS - 3

ER -