Clinical Review of the Pharmacogenomics of Direct Oral Anticoagulants

Andrew S. Tseng, Reema D. Patel, Heidi E. Quist, Adrijana Kekic, Jacob T. Maddux, Christopher B. Grilli, Fadi E. Shamoun

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Purpose: There is growing interest in the use of pharmacogenomics to optimize the safety and efficacy of anticoagulation therapy. While the pharmacogenomics of warfarin have been well-studied, the pharmacogenomics of direct oral anticoagulants (DOACs) continue to be a fledgling, but growing, field of interest. We present a pertinent clinical review of the present state of research on the pharmacogenomics of DOACs. Methods and Results: The present article is a review of pertinent clinical and scientific research on the pharmacogenomics of DOACs between January 2008 and December 2017 using MEDLINE and the United States National Institutes of Health Clinical Trials Registry. Many studies have identified single-nucleotide polymorphisms (SNPs) in genes responsible for DOAC metabolism that impacted serum DOAC concentration but had uncertain clinical significance. Conclusions: As such, there is currently no strong evidence for the use of pharmacogenomic testing in optimizing the safety and efficacy of DOAC therapy. Nonetheless, genes of interest have been identified for each DOAC that may be of potential clinical utility. Further research is currently underway to elucidate the value of pharmacogenomics in this increasingly prescribed therapy.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalCardiovascular Drugs and Therapy
DOIs
StateAccepted/In press - Feb 13 2018

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Keywords

  • Direct oral anticoagulants
  • Genetic testing
  • Pharmacogenomics
  • Safety and efficacy

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)

Cite this

Tseng, A. S., Patel, R. D., Quist, H. E., Kekic, A., Maddux, J. T., Grilli, C. B., & Shamoun, F. E. (Accepted/In press). Clinical Review of the Pharmacogenomics of Direct Oral Anticoagulants. Cardiovascular Drugs and Therapy, 1-6. https://doi.org/10.1007/s10557-018-6774-1