Clinical relevance of natural killer cells following hematopoietic stem cell transplantation

Jeanne Palmer, Kamalakannan Rajasekaran, Monica S. Thakar, Subramaniam Malarkannan

Research output: Contribution to journalReview article

31 Citations (Scopus)

Abstract

Natural killer (NK) cells are one of the first cells to recover following allogeneic hematopoietic stem cell transplantation (HSCT), and are believed to play an important role in facilitating engraftment or preventing post-transplant infection and tumor recurrence. Recent studies have provided novel insights into the mechanisms by which NK cells mediate these highly clinically relevant immunological functions. In particular, the ability of NK cells to reduce the risk of graft versus host disease (GVHD) and increase the graft versus leukemia effect (GVL) in the setting of human leukocyte antigen (HLA)-haploidentical HSCT highlights their clinical potentials. NK cells also mediate anti-viral protection, in particular against cytomegalovirus (CMV), an infection that causes significant morbidity and mortality following transplant. Another crucial function of NK cells is providing protection against bacterial infections at the mucosal barriers. NK cells achieve this by promoting anti-microbial defenses and regeneration of epithelial cells. These recent exciting findings provide a strong basis for the formulation of novel NK cell-based immunotherapies. In this review, we summarize the recent advances related to the mechanisms, functions, and future clinical prospects of NK cells that can impact post-transplant outcomes.

Original languageEnglish (US)
Pages (from-to)25-35
Number of pages11
JournalJournal of Cancer
Volume4
Issue number1
DOIs
StatePublished - Aug 30 2013
Externally publishedYes

Fingerprint

Hematopoietic Stem Cell Transplantation
Natural Killer Cells
Transplants
Cytomegalovirus Infections
Graft vs Host Disease
HLA Antigens
Bacterial Infections
Immunotherapy
Regeneration
Leukemia
Epithelial Cells
Morbidity
Recurrence
Mortality
Infection

Keywords

  • Immunological functions
  • Natural killer cells
  • Post-transplant
  • Stem cell

ASJC Scopus subject areas

  • Oncology

Cite this

Clinical relevance of natural killer cells following hematopoietic stem cell transplantation. / Palmer, Jeanne; Rajasekaran, Kamalakannan; Thakar, Monica S.; Malarkannan, Subramaniam.

In: Journal of Cancer, Vol. 4, No. 1, 30.08.2013, p. 25-35.

Research output: Contribution to journalReview article

Palmer, Jeanne ; Rajasekaran, Kamalakannan ; Thakar, Monica S. ; Malarkannan, Subramaniam. / Clinical relevance of natural killer cells following hematopoietic stem cell transplantation. In: Journal of Cancer. 2013 ; Vol. 4, No. 1. pp. 25-35.
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