Clinical progression of methicillin-resistant Staphylococcus aureus vertebral osteomyelitis associated with reduced susceptibility to daptomycin

Holenarasipur R. Vikram, Nancy L. Havill, Laura M. Koeth, John M. Boyce

Research output: Contribution to journalArticle

69 Scopus citations


Daptomycin, a novel cyclic lipopeptide antibiotic, exhibits rapid bactericidal activity in vitro against most clinically relevant gram-posiiive organisms, including drug-resistant pathogens. Herein we describe a patient in whom methicillin-resisiant Staphylococcus aureus with reduced susceptibility to daptomycin was responsible for bacteremia and progressive vertebral osteomyelitis during daptomycin therapy.

Original languageEnglish (US)
Pages (from-to)5384-5387
Number of pages4
JournalJournal of Clinical Microbiology
Issue number10
StatePublished - Oct 2005


ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology

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