TY - JOUR
T1 - Clinical profile of autoimmune pancreatitis and its histological subtypes
T2 - An international multicenter survey
AU - Kamisawa, Terumi
AU - Chari, Suresh T.
AU - Giday, Samuel A.
AU - Kim, Myung Hwan
AU - Chung, Jae Bock
AU - Lee, Kyu Taek
AU - Werner, Jens
AU - Bergmann, Frank
AU - Lerch, Markus M.
AU - Mayerle, Julia
AU - Pickartz, Tilman
AU - Lohr, Matthias
AU - Schneider, Alexander
AU - Frulloni, Luca
AU - Webster, George J.M.
AU - Reddy, D. Nageshwar
AU - Liao, Wei Chih
AU - Wang, Hsiu Po
AU - Okazaki, Kazuichi
AU - Shimosegawa, Tooru
AU - Kloeppel, Guenter
AU - Go, Vay Liang W.
PY - 2011/8
Y1 - 2011/8
N2 - Objective: The objective of this study was to clarify the clinical and pathophysiological characteristics of autoimmune pancreatitis (AIP) and its subtypes (lymphoplasmacytic sclerosing pancreatitis [LPSP] and idiopathic duct-centric pancreatitis [IDCP]) seen around the world. Methods: An international multicenter survey of AIP was conducted in 15 institutes from 8 countries. We compared clinical and pathologic profiles of AIP (n = 731) and the clinical profiles of LPSP (n = 204) and IDCP (n = 64) patients. Results: Patients with LPSP were approximately 16 years older than IDCP patients. Obstructive jaundice was a more frequent presentation in LPSP versus IDCP (75% vs 47%, P < 0.001), whereas abdominal pain (41% vs 68%, P < 0.001) and acute pancreatitis (5% vs 34%, P < 0.001) were more frequent in IDCP patients. Patients with LPSP were more likely to have diffuse swelling of the pancreas (40% vs 25%, P = 0.037) and elevated serum IgG4 levels (63% vs 23%, P < 0.001) but less likely to be associated with ulcerative colitis (1% vs 16%, P < 0.001). Clinical profiles of non-histologically confirmed AIP from Asia, the United States, and United Kingdom corresponded with that of LPSP, whereas those from Italy and Germany suggested a mixture of LPSP and IDCP. Conclusions: Autoimmune pancreatitis is seen all around the world, with regional differences in the pathologic and clinical features. Lymphoplasmacytic sclerosing pancreatitis and IDCP have distinct clinical profiles.
AB - Objective: The objective of this study was to clarify the clinical and pathophysiological characteristics of autoimmune pancreatitis (AIP) and its subtypes (lymphoplasmacytic sclerosing pancreatitis [LPSP] and idiopathic duct-centric pancreatitis [IDCP]) seen around the world. Methods: An international multicenter survey of AIP was conducted in 15 institutes from 8 countries. We compared clinical and pathologic profiles of AIP (n = 731) and the clinical profiles of LPSP (n = 204) and IDCP (n = 64) patients. Results: Patients with LPSP were approximately 16 years older than IDCP patients. Obstructive jaundice was a more frequent presentation in LPSP versus IDCP (75% vs 47%, P < 0.001), whereas abdominal pain (41% vs 68%, P < 0.001) and acute pancreatitis (5% vs 34%, P < 0.001) were more frequent in IDCP patients. Patients with LPSP were more likely to have diffuse swelling of the pancreas (40% vs 25%, P = 0.037) and elevated serum IgG4 levels (63% vs 23%, P < 0.001) but less likely to be associated with ulcerative colitis (1% vs 16%, P < 0.001). Clinical profiles of non-histologically confirmed AIP from Asia, the United States, and United Kingdom corresponded with that of LPSP, whereas those from Italy and Germany suggested a mixture of LPSP and IDCP. Conclusions: Autoimmune pancreatitis is seen all around the world, with regional differences in the pathologic and clinical features. Lymphoplasmacytic sclerosing pancreatitis and IDCP have distinct clinical profiles.
KW - IgG4
KW - chronic pancreatitis
KW - idiopathic duct-centric pancreatitis
KW - lymphoplasmacytic sclerosing pancreatitis
UR - http://www.scopus.com/inward/record.url?scp=80051551586&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80051551586&partnerID=8YFLogxK
U2 - 10.1097/MPA.0b013e3182258a15
DO - 10.1097/MPA.0b013e3182258a15
M3 - Review article
C2 - 21747310
AN - SCOPUS:80051551586
SN - 0885-3177
VL - 40
SP - 809
EP - 814
JO - Pancreas
JF - Pancreas
IS - 6
ER -