Clinical Presentation and Outcomes of Pregnant Women With Coronavirus Disease 2019: A Systematic Review and Meta-analysis

Reem Matar, Layan Alrahmani, Nasser Monzer, Labib G. Debiane, Elie Berbari, Jawad Fares, Fidelma Fitzpatrick, Mohammad H. Murad

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

BACKGROUND: Descriptions of coronavirus disease 2019 (COVID-19) have focused on the nonpregnant adult population. This study aims to describe the clinical characteristics and perinatal outcomes of COVID-19 in pregnancy. METHODS: We searched databases from December 2019 to 30 April 2020. Eligible studies reported clinical characteristics, radiological findings, and/or laboratory testing of pregnant women during infection. Data were pooled across studies using a random-effects model. RESULTS: Twenty-four studies (136 women) were included. The most common symptoms were fever (62.9%) and cough (36.8%). Laboratory findings included elevated C-reactive protein (57%) and lymphocytopenia (50%). Ground-glass opacity was the most common radiological finding (81.7%). Preterm birth rate was 37.7% and cesarean delivery rate was 76%. There was 1 maternal death. There were 2 fetal COVID-19 cases. CONCLUSIONS: The clinical picture in pregnant women with COVID-19 did not differ from the nonpregnant population; however, the rate of preterm birth and cesarean delivery are considerably higher than international averages.

Original languageEnglish (US)
Pages (from-to)521-533
Number of pages13
JournalClinical infectious diseases : an official publication of the Infectious Diseases Society of America
Volume72
Issue number3
DOIs
StatePublished - Feb 1 2021

Keywords

  • coronavirus
  • neonates
  • pregnant
  • transmission

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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