TY - JOUR
T1 - Clinical pathophysiology of the somatotropic (GH) axis in adults
AU - Iranmanesh, A.
AU - Veldhuis, J. D.
PY - 1992
Y1 - 1992
N2 - In summary, GH secretion and, to a lesser extent, GH metabolic clearance, are subject to regulation in health and disease. Nutritional, body compositional, metabolic, and age-related and sex-steroid related mechanisms as well as adrenal glucocorticoids, thyroid hormones, and renal and hepatic function all govern pulsatile GH release in adults. Moreover, tissue resistance to GH action may occur as an inborn (Laron dwarf) or acquired (fasting, diabetes mellitus, chronic renal failure) defect and modulate the function of the somatotropic axis. Finally, GH action is controlled by the local synthesis of IGFs and their binding proteins in target tissues.
AB - In summary, GH secretion and, to a lesser extent, GH metabolic clearance, are subject to regulation in health and disease. Nutritional, body compositional, metabolic, and age-related and sex-steroid related mechanisms as well as adrenal glucocorticoids, thyroid hormones, and renal and hepatic function all govern pulsatile GH release in adults. Moreover, tissue resistance to GH action may occur as an inborn (Laron dwarf) or acquired (fasting, diabetes mellitus, chronic renal failure) defect and modulate the function of the somatotropic axis. Finally, GH action is controlled by the local synthesis of IGFs and their binding proteins in target tissues.
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U2 - 10.1016/s0889-8529(18)30189-0
DO - 10.1016/s0889-8529(18)30189-0
M3 - Review article
C2 - 1486876
AN - SCOPUS:0026619132
SN - 0889-8529
VL - 21
SP - 783
EP - 816
JO - Endocrinology and Metabolism Clinics of North America
JF - Endocrinology and Metabolism Clinics of North America
IS - 4
ER -