Clinical, pathologic, cytogenetic, and molecular profiling in self-identified black women with uterine leiomyomata

Mark A. Hayden, Zehra Ordulu, C. Scott Gallagher, Bradley J. Quade, Raymond M. Anchan, Nia Robinson Middleton, Serene S. Srouji, Elizabeth A Stewart, Cynthia C. Morton

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Black women are disproportionately affected by uterine leiomyomata (UL), or fibroids, compared to other racial groups, having a greater lifetime risk of developing UL and an earlier age of diagnosis. In order to elucidate molecular and genetic mechanisms responsible for the increased prevalence and morbidity associated with UL in black women, clinical, pathologic, cytogenetic, and select molecular profiling (MED12 mutation analysis) of 75 self-reported black women undergoing surgical treatment for UL was performed. Our observations are broadly representative of previous cytogenetic studies of UL: karyotypically abnormal tumors were detected in 30.7% of women and 17.4% of analyzed tumors. No notable association was observed between race and increased occurrence of cytogenetic abnormalities that might contribute to any population-specific morbidity or prevalence rate. Our data on MED12 mutation analyses (73.2% of tumors harbored a MED12 mutation) provide additional support for a significant role of MED12 in tumorigenesis. Although the effect of MED12-mediated tumorigenesis appears significant irrespective of race, other genetic events such as the distribution of karyotypic abnormalities appear differently in black women. This case series indicates that presently recognized genetic and molecular characteristics of UL do not appear to explain the increased prevalence and morbidity of UL in black women.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalCancer genetics
Volume222-223
DOIs
StatePublished - Apr 1 2018

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Leiomyoma
Cytogenetics
Morbidity
Mutation
Molecular Biology
Carcinogenesis
Neoplasms
Chromosome Aberrations
Early Diagnosis
Population

Keywords

  • clinical
  • cytogenetic
  • Fibroids
  • molecular
  • race

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

Cite this

Hayden, M. A., Ordulu, Z., Gallagher, C. S., Quade, B. J., Anchan, R. M., Middleton, N. R., ... Morton, C. C. (2018). Clinical, pathologic, cytogenetic, and molecular profiling in self-identified black women with uterine leiomyomata. Cancer genetics, 222-223, 1-8. https://doi.org/10.1016/j.cancergen.2018.01.001

Clinical, pathologic, cytogenetic, and molecular profiling in self-identified black women with uterine leiomyomata. / Hayden, Mark A.; Ordulu, Zehra; Gallagher, C. Scott; Quade, Bradley J.; Anchan, Raymond M.; Middleton, Nia Robinson; Srouji, Serene S.; Stewart, Elizabeth A; Morton, Cynthia C.

In: Cancer genetics, Vol. 222-223, 01.04.2018, p. 1-8.

Research output: Contribution to journalArticle

Hayden, MA, Ordulu, Z, Gallagher, CS, Quade, BJ, Anchan, RM, Middleton, NR, Srouji, SS, Stewart, EA & Morton, CC 2018, 'Clinical, pathologic, cytogenetic, and molecular profiling in self-identified black women with uterine leiomyomata', Cancer genetics, vol. 222-223, pp. 1-8. https://doi.org/10.1016/j.cancergen.2018.01.001
Hayden, Mark A. ; Ordulu, Zehra ; Gallagher, C. Scott ; Quade, Bradley J. ; Anchan, Raymond M. ; Middleton, Nia Robinson ; Srouji, Serene S. ; Stewart, Elizabeth A ; Morton, Cynthia C. / Clinical, pathologic, cytogenetic, and molecular profiling in self-identified black women with uterine leiomyomata. In: Cancer genetics. 2018 ; Vol. 222-223. pp. 1-8.
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