Clinical, pathologic, and serologic features of an epizootic of mousepox in Minnesota

P. J. Manning, C. S. Frisk

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Citations (Scopus)

Abstract

An epizootic of mousepox in two colonies of mice was described. Clinical signs, morbidity and mortality rates, and necropsy lesions were substantially influenced by husbandry practices, intercurrent diseases (Sendai pneumonia, mouse hepatitis virus), and total body x-irradiation. In one colony, 54 mice were necropsied; 19 mice had cutaneous or visceral lesions of mousepox although none had combined visceral and cutaneous lesions. In the other colony, 20 mice were necropsied, and 10 mice had cutaneous lesions; none had visceral lesions. Sera from 24 mice with the cutaneous form of the disease had no demonstrable HI antibody titer. Experimental mice injected with spleen/liver homogenates from infected colony mice developed typical visceral lesions with numerous poxvirus profiles on electron micrographs and positive HI titers. Mice immunized with vaccinia virus were not susceptible to the disease.

Original languageEnglish (US)
Title of host publicationLaboratory Animal Science
Pages574-577
Number of pages4
Volume31
Edition5 II
StatePublished - 1981
Externally publishedYes

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Infectious Ectromelia
Skin
Murine hepatitis virus
Poxviridae
Vaccinia virus
Whole-Body Irradiation
Skin Diseases
Pneumonia

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Manning, P. J., & Frisk, C. S. (1981). Clinical, pathologic, and serologic features of an epizootic of mousepox in Minnesota. In Laboratory Animal Science (5 II ed., Vol. 31, pp. 574-577)

Clinical, pathologic, and serologic features of an epizootic of mousepox in Minnesota. / Manning, P. J.; Frisk, C. S.

Laboratory Animal Science. Vol. 31 5 II. ed. 1981. p. 574-577.

Research output: Chapter in Book/Report/Conference proceedingChapter

Manning, PJ & Frisk, CS 1981, Clinical, pathologic, and serologic features of an epizootic of mousepox in Minnesota. in Laboratory Animal Science. 5 II edn, vol. 31, pp. 574-577.
Manning PJ, Frisk CS. Clinical, pathologic, and serologic features of an epizootic of mousepox in Minnesota. In Laboratory Animal Science. 5 II ed. Vol. 31. 1981. p. 574-577
Manning, P. J. ; Frisk, C. S. / Clinical, pathologic, and serologic features of an epizootic of mousepox in Minnesota. Laboratory Animal Science. Vol. 31 5 II. ed. 1981. pp. 574-577
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