Clinical Outcomes after Surgery for Linitis Plastica of the Stomach: Analysis of a Population Cancer Registry

James M. Chang, Kelly A. Lara, Richard J. Gray, Barbara A Pockaj, Nabil Wasif

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Linitis plastica (LP), a subset of gastric adenocarcinoma (GA), has been considered as a fatal disease with few management options. Little evidence has been reported regarding the role for surgical therapy in treating LP. A retrospective review of GA patients with LP from the surveillance, epidemiology, and end results database (2004-2009) was performed. 29,440 patients with GA were identified, of whom 948 (3.2%) had LP. After matching for American Joint Commission on Cancer (AJCC) stage, LP patients had significantly worse 5-year disease specific survival (DSS) compared with GA (6 vs 34%, P < 0.001). For potentially resectable LP patients (i.e., stage I-III), 5-year DSS was 0 per cent for no treatment and for radiation therapy alone, 18 per cent for both and surgery and radiation, and 20 per cent for surgery alone(P < 0.001). LP is a marker of poor survival in patients with GA. However, surgical resection provides the best oncologic outcomes in these patients with a 20 per cent 5-year DSS in patients with loco-regional disease.

Original languageEnglish (US)
Pages (from-to)23-29
Number of pages7
JournalThe American surgeon
Volume83
Issue number1
StatePublished - Jan 1 2017

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Linitis Plastica
Registries
Stomach
Adenocarcinoma
Population
Neoplasms
Survival
Epidemiology
Radiotherapy
Joints
Databases
Radiation

ASJC Scopus subject areas

  • Surgery
  • Medicine(all)

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Clinical Outcomes after Surgery for Linitis Plastica of the Stomach : Analysis of a Population Cancer Registry. / Chang, James M.; Lara, Kelly A.; Gray, Richard J.; Pockaj, Barbara A; Wasif, Nabil.

In: The American surgeon, Vol. 83, No. 1, 01.01.2017, p. 23-29.

Research output: Contribution to journalArticle

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