Clinical outcome of patients with subcutaneous panniculitis-like T-cell lymphoma

Irene M. Ghobrial, Roger H. Weenig, Mark R. Pittlekow, Guangzhi Qu, Paul J. Kurtin, Kay Ristow, Stephen M. Ansell

Research output: Contribution to journalArticle

49 Scopus citations

Abstract

Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare form of cytotoxic T-cell lymphoma. The objective of this study was to characterize the clinical presentation, treatment, and prognosis of patients with SPTCL. Twenty-one patients with SPTCL were seen at Mayo Clinic (Rochester, Minnesota, USA) between July 1973 and June 2004. The median age at diagnosis was 42 years (range 23-80 years) and 15 (71%) were women. Constitutional symptoms occurred in 14 (67%) patients, including fever, serositis, arthralgias and myalgias. The Eastern Cooperative Oncology Group performance score was poor (3-4) in 3 (15%) patients. Liver enzymes (at least 2 enzymes, Aspartate aminotransferase (AST), alkaline phosphatase and/or lactate dehydrogenase) were elevated in 11 (52%) patients. Therapy consisted of chemotherapy in 13 (62%) patients, or other therapeutic interventions in 8 (38%) patients, including surgical excision, corticosteroids alone or in combination with either plaquenil, colchicine, hydroxychoroquine, or azathioprine. Bone marrow transplantation was performed in 5 (24%) patients, 3 autologous and 2 allogeneic. The median overall survival from diagnosis was 15 months (range 0.1-104 months). Two groups of patients were identified and categorized as having a favorable or unfavorable disease course. The factors associated with an unfavorable disease course were a low white blood cell count or elevated lactate dehydrogenase. Patients treated aggressively with stem cell transplantation appeared to have an improved overall survival.

Original languageEnglish (US)
Pages (from-to)703-708
Number of pages6
JournalLeukemia and Lymphoma
Volume46
Issue number5
DOIs
StatePublished - May 1 2005

Keywords

  • Lymphoma
  • Panniculitis
  • T cell
  • Transplant

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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    Ghobrial, I. M., Weenig, R. H., Pittlekow, M. R., Qu, G., Kurtin, P. J., Ristow, K., & Ansell, S. M. (2005). Clinical outcome of patients with subcutaneous panniculitis-like T-cell lymphoma. Leukemia and Lymphoma, 46(5), 703-708. https://doi.org/10.1080/10428190500051380