Abstract
Myelodysplastic syndrome unclassifiable (MDS-U) is a small subtype of myelodysplastic syndromes (MDS). However, rare literature exists in terms of natural progression and clinical outcome of patients with MDS-U. In the present study, we investigated the characteristics and the clinical outcomes of patients categorized as MDS-U based on 2008 World Health Organization criteria (WHO) in a single center comparing to other MDS groups. Out of eight hundred and two patients who met WHO criteria for MDS at our institution, ninety patients (11%) were initially classified as MDS-U. Upon pathological review, only half of the cases were confirmed to be MDS-U. With follow up, half of the MDS-U cases were reclassified to another subtype. We found neither significant difference in median overall survival nor in risk of transformation to acute myeloid leukemia when comparing MDS-U to other MDS groups. Additional larger studies are needed to confirm our results.
Original language | English (US) |
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Pages (from-to) | 2483-2487 |
Number of pages | 5 |
Journal | Leukemia and Lymphoma |
Volume | 60 |
Issue number | 10 |
DOIs | |
State | Published - Aug 24 2019 |
Keywords
- Myelodysplastic syndrome
- World Health Organization
- overall survival
- unclassifiable
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research