Clinical outcome of patients diagnosed with myelodysplastic syndrome-unclassifiable (MDS-U): single center experience

Firas Baidoun, Dong Chen, Mrinal M Patnaik, Naseema Gangat, Kebede Begna, Michelle Elliott, William Hogan, Mark R Litzow, Aref Al-Kali

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Myelodysplastic syndrome unclassifiable (MDS-U) is a small subtype of myelodysplastic syndromes (MDS). However, rare literature exists in terms of natural progression and clinical outcome of patients with MDS-U. In the present study, we investigated the characteristics and the clinical outcomes of patients categorized as MDS-U based on 2008 World Health Organization criteria (WHO) in a single center comparing to other MDS groups. Out of eight hundred and two patients who met WHO criteria for MDS at our institution, ninety patients (11%) were initially classified as MDS-U. Upon pathological review, only half of the cases were confirmed to be MDS-U. With follow up, half of the MDS-U cases were reclassified to another subtype. We found neither significant difference in median overall survival nor in risk of transformation to acute myeloid leukemia when comparing MDS-U to other MDS groups. Additional larger studies are needed to confirm our results.

Original languageEnglish (US)
JournalLeukemia and Lymphoma
DOIs
StatePublished - Jan 1 2019

Keywords

  • Myelodysplastic syndrome
  • overall survival
  • unclassifiable
  • World Health Organization

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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