Clinical outcome of immunoglobulin light chain amyloidosis affecting the kidney

Morie A. Gertz, Nelson Leung, Martha Q. Lacy, Angela Dispenzieri, Steven R. Zeldenrust, Suzanne R. Hayman, Francis K. Buadi, David Dingli, Philip R. Greipp, Shaji K. Kumar, John A. Lust, S. Vincent Rajkumar, Stephen J. Russell, Thomas E. Witzig

Research output: Contribution to journalArticle

73 Scopus citations

Abstract

Background. The kidney is affected by immunoglobulin light chain amyloidosis (AL) in more than 50 of patients who present with the disease, but long-term predictors for and outcomes after renal replacement therapy are not well described.Methods. Kaplan-Meier and multivariate analyses were performed in a uniformly treated cohort of 145 patients with biopsy-proven AL who were monitored for at least 11 years. Outcome measurements were needed for renal replacement therapy and survival.Results. Among patients presenting with renal AL, 42 ultimately received renal replacement therapy versus 5 of patients who did not have this presentation. Patients with renal amyloid who received dialysis support had significantly higher serum creatinine and 24-h urine protein levels at presentation. Patients with λ light chain amyloid were significantly more likely to have renal involvement and had significantly greater urinary protein loss than patients with κ light chain amyloid. Serum creatinine level was an independent predictor of overall survival when corrected for cardiac involvement. For 38 patients who received dialysis, median survival from Day 1 of dialysis was 10.4 months, and 26 of patients with AL ultimately received renal replacement therapy versus 42 of patients who presented with renal AL specifically.Conclusions. Presenting 24-h urine protein loss and creatinine values predict which patients will require dialysis. Median survival for patients starting dialysis is <1 year. The presence of λ light chain amyloid predicts the increased likelihood of renal involvement.

Original languageEnglish (US)
Pages (from-to)3132-3137
Number of pages6
JournalNephrology Dialysis Transplantation
Volume24
Issue number10
DOIs
StatePublished - Oct 1 2009

Keywords

  • Amyloidosis
  • Dialysis
  • Immunoglobulin light chains
  • Proteinuria
  • Renal failure

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

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