TY - JOUR
T1 - Clinical outcome in pleomorphic lobular carcinoma
T2 - A case-control study with comparison to classic invasive lobular carcinoma
AU - Narendra, Sonia
AU - Jenkins, Sarah M.
AU - Khoor, Andras
AU - Nassar, Aziza
N1 - Publisher Copyright:
© 2015 Elsevier Inc. All rights reserved.
PY - 2015/4/1
Y1 - 2015/4/1
N2 - Abstract Pleomorphic lobular carcinoma (PLC), a variant of invasive lobular carcinoma (ILC) is described as an aggressive tumor with poor prognosis. Multiple studies show lower overall survival for patients with PLC than for patients with classic ILC (cILC). We compared the clinicopathologic characteristics of PLC with those of cILC. All cases with a diagnosis of ILC, Nottingham grades 2 or 3 that were diagnosed between January 1, 1990, and December 31, 2010, were retrieved from pathology files in the institutional anatomic pathology database. The cases (N = 52) were reviewed to identify those meeting the criteria for PLC. An E-cadherin immunostain was used to confirm the lobular immunophenotype. Clinicopathologic data were assessed and analyzed. A control group (N = 103) of cILC, Nottingham grade 1, was selected, with 2 controls for each case, matched by age and year of diagnosis. PLC was associated more closely with in situ carcinoma (P =.03), and had lower progesterone receptor expression (P =.03) than cILC. Both disease-free survival and overall survival were similar between patients with PLC and matched cILC controls, and both depended on disease stage, tumor size, and lymph node status. PLC is similar to cILC in terms of patient survival and outcomes.
AB - Abstract Pleomorphic lobular carcinoma (PLC), a variant of invasive lobular carcinoma (ILC) is described as an aggressive tumor with poor prognosis. Multiple studies show lower overall survival for patients with PLC than for patients with classic ILC (cILC). We compared the clinicopathologic characteristics of PLC with those of cILC. All cases with a diagnosis of ILC, Nottingham grades 2 or 3 that were diagnosed between January 1, 1990, and December 31, 2010, were retrieved from pathology files in the institutional anatomic pathology database. The cases (N = 52) were reviewed to identify those meeting the criteria for PLC. An E-cadherin immunostain was used to confirm the lobular immunophenotype. Clinicopathologic data were assessed and analyzed. A control group (N = 103) of cILC, Nottingham grade 1, was selected, with 2 controls for each case, matched by age and year of diagnosis. PLC was associated more closely with in situ carcinoma (P =.03), and had lower progesterone receptor expression (P =.03) than cILC. Both disease-free survival and overall survival were similar between patients with PLC and matched cILC controls, and both depended on disease stage, tumor size, and lymph node status. PLC is similar to cILC in terms of patient survival and outcomes.
KW - Classic lobular carcinoma
KW - Outcome
KW - Pleomorphic lobular carcinoma
KW - Survival
UR - http://www.scopus.com/inward/record.url?scp=84925136848&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84925136848&partnerID=8YFLogxK
U2 - 10.1016/j.anndiagpath.2015.01.005
DO - 10.1016/j.anndiagpath.2015.01.005
M3 - Article
C2 - 25682191
AN - SCOPUS:84925136848
SN - 1092-9134
VL - 19
SP - 64
EP - 69
JO - Annals of Diagnostic Pathology
JF - Annals of Diagnostic Pathology
IS - 2
ER -