TY - JOUR
T1 - Clinical knowledge-based inference model for early detection of acute lung injury
AU - Chbat, Nicolas W.
AU - Chu, Weiwei
AU - Ghosh, Monisha
AU - Li, Guangxi
AU - Li, Man
AU - Chiofolo, Caitlyn M.
AU - Vairavan, Srinivasan
AU - Herasevich, Vitaly
AU - Gajic, Ognjen
N1 - Funding Information:
This work was partially supported by the NIH Grant RC1 LM10468Z-01.
PY - 2012/5
Y1 - 2012/5
N2 - Acute lung injury (ALI) is a devastating complication of acute illness and one of the leading causes of multiple organ failure and mortality in the intensive care unit (ICU). The detection of this syndrome is limited due to the complexity of the disease, insufficient understanding of its development and progression, and the large amount of risk factors and modifiers. In this preliminary study, we present a novel mathematical model for ALI detection. It is constructed based on clinical and research knowledge using three complementary techniques: rule-based fuzzy inference systems, Bayesian networks, and finite state machines. The model is developed in Matlab®'s Simulink environment and takes as input pre-ICU and ICU data feeds of critically ill patients. Results of the simulation model were validated against actual patient data from an epidemiologic study. By appropriately combining all three techniques the performance attained is in the range of 71.7-92.6% sensitivity and 60.3-78.4% specificity.
AB - Acute lung injury (ALI) is a devastating complication of acute illness and one of the leading causes of multiple organ failure and mortality in the intensive care unit (ICU). The detection of this syndrome is limited due to the complexity of the disease, insufficient understanding of its development and progression, and the large amount of risk factors and modifiers. In this preliminary study, we present a novel mathematical model for ALI detection. It is constructed based on clinical and research knowledge using three complementary techniques: rule-based fuzzy inference systems, Bayesian networks, and finite state machines. The model is developed in Matlab®'s Simulink environment and takes as input pre-ICU and ICU data feeds of critically ill patients. Results of the simulation model were validated against actual patient data from an epidemiologic study. By appropriately combining all three techniques the performance attained is in the range of 71.7-92.6% sensitivity and 60.3-78.4% specificity.
KW - Acute lung injury (ALI)
KW - Bayesian network (BN)
KW - Clinical decision support (CDS)
KW - Finite state machine (FSM)
KW - Fuzzy inference system (FIS)
KW - Intensive care unit (ICU)
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U2 - 10.1007/s10439-011-0475-2
DO - 10.1007/s10439-011-0475-2
M3 - Article
C2 - 22167531
AN - SCOPUS:84862020078
SN - 0090-6964
VL - 40
SP - 1131
EP - 1141
JO - Annals of Biomedical Engineering
JF - Annals of Biomedical Engineering
IS - 5
ER -