Clinical-histological associations in gastroparesis: Results from the Gastroparesis Clinical Research Consortium

M. Grover; C. E. Bernard; P. J. Pasricha; M. S. Lurken; M. S. Faussone-Pellegrini; T. C. Smyrk; H. P. Parkman; T. L. Abell; W. J. Snape; W. L. Hasler; R. W. Mccallum; L. Nguyen; K. L. Koch; J. Calles; L. Lee; J. Tonascia; A. Ünalp-Arida; F. A. Hamilton; G. Farrugia; Nighat Ullah; Robin Bishop; Nata De Vole; Mary Greene; Sue Louiseau; Shelly Parker; Eve Pillor; Courtney Ponsetto; Katerina Shetler; K. Robert Shen; Michael Sarr; Michael Kendrick; Steven Kantor; Vanessa Lytes; Amiya Palit; Priyanka Sachdeva; Kellie Simmons; Sean Harbison; Irene Sarosiek; Reza Hejazi; Denise Vasquez; Natalia Vega; Michelle Atkinson; Jo Anne Fordham; Olivia Henry; Archana Kedar; Archana Valerie McNair; Danielle Spree; Lynn Baxter; Samantha Culler; Judy Hooker; Paula Stuart; Steven James; Rebecca Torrance; Rebekah Van Raaphorst; Patricia Belt; Michele Donithan; Mika Green; Milana Isaacson; Kevin Patrick May; Laura Miriel; Mark Van Natta; Ivana Vaughn; Laura Wilson; Katherine Yates

doi:10.1111/j.1365-2982.2012.01894.x

Clinical-histological associations in gastroparesis: Results from the Gastroparesis Clinical Research Consortium

M. Grover, C. E. Bernard, P. J. Pasricha, M. S. Lurken, M. S. Faussone-Pellegrini, T. C. Smyrk, H. P. Parkman, T. L. Abell, W. J. Snape, W. L. Hasler, R. W. Mccallum, L. Nguyen, K. L. Koch, J. Calles, L. Lee, J. Tonascia, A. Ünalp-Arida, F. A. Hamilton, G. Farrugia, Nighat UllahRobin Bishop, Nata De Vole, Mary Greene, Sue Louiseau, Shelly Parker, Eve Pillor, Courtney Ponsetto, Katerina Shetler, K. Robert Shen, Michael Sarr, Michael Kendrick, Steven Kantor, Vanessa Lytes, Amiya Palit, Priyanka Sachdeva, Kellie Simmons, Sean Harbison, Irene Sarosiek, Reza Hejazi, Denise Vasquez, Natalia Vega, Michelle Atkinson, Jo Anne Fordham, Olivia Henry, Archana Kedar, Archana Valerie McNair, Danielle Spree, Lynn Baxter, Samantha Culler, Judy Hooker, Paula Stuart, Steven James, Rebecca Torrance, Rebekah Van Raaphorst, Patricia Belt, Michele Donithan, Mika Green, Milana Isaacson, Kevin Patrick May, Laura Miriel, Mark Van Natta, Ivana Vaughn, Laura Wilson, Katherine Yates

Research output: Contribution to journal › Article › peer-review

112 Scopus citations

Abstract

Background Cellular changes associated with diabetic (DG) and idiopathic gastroparesis (IG) have recently been described from patients enrolled in the Gastroparesis Clinical Research Consortium. The association of these cellular changes with gastroparesis symptoms and gastric emptying is unknown. The aim of this study was to relate cellular changes to symptoms and gastric emptying in patients with gastroparesis. Methods Earlier, using full thickness gastric body biopsies from 20 DG, 20 IG, and 20 matched controls, we found decreased interstitial cells of Cajal (ICC) and enteric nerves and an increase in immune cells in both DG and IG. Here, demographic, symptoms [gastroparesis cardinal symptom index score (GCSI)], and gastric emptying were related to cellular alterations using Pearson's correlation coefficients. Key Results Interstitial cells of Cajal counts inversely correlated with 4h gastric retention in DG but not in IG (r=-0.6, P=0.008, DG, r=0.2, P=0.4, IG). There was also a significant correlation between loss of ICC and enteric nerves in DG but not in IG (r=0.5, P=0.03 for DG, r=0.3, P=0.16, IG). Idiopathic gastroparesis with a myenteric immune infiltrate scored higher on the average GCSI (3.6±0.7 vs 2.7±0.9, P=0.05) and nausea score (3.8±0.9 vs 2.6±1.0, P=0.02) as compared to those without an infiltrate. Conclusions & Inferences In DG, loss of ICC is associated with delayed gastric emptying. Interstitial cells of Cajal or enteric nerve loss did not correlate with symptom severity. Overall clinical severity and nausea in IG is associated with a myenteric immune infiltrate. Thus, full thickness gastric biopsies can help define specific cellular abnormalities in gastroparesis, some of which are associated with physiological and clinical characteristics of gastroparesis.

Original language	English (US)
Pages (from-to)	531-e249
Journal	Neurogastroenterology and Motility
Volume	24
Issue number	6
DOIs	https://doi.org/10.1111/j.1365-2982.2012.01894.x
State	Published - Jun 1 2012

Keywords

Clinical symptoms
Enteric nervous system
Gastric emptying
Gastroparesis
Interstitial cells of Cajal
Macrophages

ASJC Scopus subject areas

Physiology
Endocrine and Autonomic Systems
Gastroenterology

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10.1111/j.1365-2982.2012.01894.x

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Grover, M., Bernard, C. E., Pasricha, P. J., Lurken, M. S., Faussone-Pellegrini, M. S., Smyrk, T. C., Parkman, H. P., Abell, T. L., Snape, W. J., Hasler, W. L., Mccallum, R. W., Nguyen, L., Koch, K. L., Calles, J., Lee, L., Tonascia, J., Ünalp-Arida, A., Hamilton, F. A., Farrugia, G., ... Yates, K. (2012). Clinical-histological associations in gastroparesis: Results from the Gastroparesis Clinical Research Consortium. Neurogastroenterology and Motility, 24(6), 531-e249. https://doi.org/10.1111/j.1365-2982.2012.01894.x

Grover, M, Bernard, CE, Pasricha, PJ, Lurken, MS, Faussone-Pellegrini, MS, Smyrk, TC, Parkman, HP, Abell, TL, Snape, WJ, Hasler, WL, Mccallum, RW, Nguyen, L, Koch, KL, Calles, J, Lee, L, Tonascia, J, Ünalp-Arida, A, Hamilton, FA, Farrugia, G, Ullah, N, Bishop, R, De Vole, N, Greene, M, Louiseau, S, Parker, S, Pillor, E, Ponsetto, C, Shetler, K, Shen, KR, Sarr, M, Kendrick, M, Kantor, S, Lytes, V, Palit, A, Sachdeva, P, Simmons, K, Harbison, S, Sarosiek, I, Hejazi, R, Vasquez, D, Vega, N, Atkinson, M, Fordham, JA, Henry, O, Kedar, A, McNair, AV, Spree, D, Baxter, L, Culler, S, Hooker, J, Stuart, P, James, S, Torrance, R, Van Raaphorst, R, Belt, P, Donithan, M, Green, M, Isaacson, M, May, KP, Miriel, L, Van Natta, M, Vaughn, I, Wilson, L & Yates, K 2012, 'Clinical-histological associations in gastroparesis: Results from the Gastroparesis Clinical Research Consortium', Neurogastroenterology and Motility, vol. 24, no. 6, pp. 531-e249. https://doi.org/10.1111/j.1365-2982.2012.01894.x

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title = "Clinical-histological associations in gastroparesis: Results from the Gastroparesis Clinical Research Consortium",

abstract = "Background Cellular changes associated with diabetic (DG) and idiopathic gastroparesis (IG) have recently been described from patients enrolled in the Gastroparesis Clinical Research Consortium. The association of these cellular changes with gastroparesis symptoms and gastric emptying is unknown. The aim of this study was to relate cellular changes to symptoms and gastric emptying in patients with gastroparesis. Methods Earlier, using full thickness gastric body biopsies from 20 DG, 20 IG, and 20 matched controls, we found decreased interstitial cells of Cajal (ICC) and enteric nerves and an increase in immune cells in both DG and IG. Here, demographic, symptoms [gastroparesis cardinal symptom index score (GCSI)], and gastric emptying were related to cellular alterations using Pearson's correlation coefficients. Key Results Interstitial cells of Cajal counts inversely correlated with 4h gastric retention in DG but not in IG (r=-0.6, P=0.008, DG, r=0.2, P=0.4, IG). There was also a significant correlation between loss of ICC and enteric nerves in DG but not in IG (r=0.5, P=0.03 for DG, r=0.3, P=0.16, IG). Idiopathic gastroparesis with a myenteric immune infiltrate scored higher on the average GCSI (3.6±0.7 vs 2.7±0.9, P=0.05) and nausea score (3.8±0.9 vs 2.6±1.0, P=0.02) as compared to those without an infiltrate. Conclusions & Inferences In DG, loss of ICC is associated with delayed gastric emptying. Interstitial cells of Cajal or enteric nerve loss did not correlate with symptom severity. Overall clinical severity and nausea in IG is associated with a myenteric immune infiltrate. Thus, full thickness gastric biopsies can help define specific cellular abnormalities in gastroparesis, some of which are associated with physiological and clinical characteristics of gastroparesis.",

keywords = "Clinical symptoms, Enteric nervous system, Gastric emptying, Gastroparesis, Interstitial cells of Cajal, Macrophages",

author = "M. Grover and Bernard, {C. E.} and Pasricha, {P. J.} and Lurken, {M. S.} and Faussone-Pellegrini, {M. S.} and Smyrk, {T. C.} and Parkman, {H. P.} and Abell, {T. L.} and Snape, {W. J.} and Hasler, {W. L.} and Mccallum, {R. W.} and L. Nguyen and Koch, {K. L.} and J. Calles and L. Lee and J. Tonascia and A. {\"U}nalp-Arida and Hamilton, {F. A.} and G. Farrugia and Nighat Ullah and Robin Bishop and {De Vole}, Nata and Mary Greene and Sue Louiseau and Shelly Parker and Eve Pillor and Courtney Ponsetto and Katerina Shetler and Shen, {K. Robert} and Michael Sarr and Michael Kendrick and Steven Kantor and Vanessa Lytes and Amiya Palit and Priyanka Sachdeva and Kellie Simmons and Sean Harbison and Irene Sarosiek and Reza Hejazi and Denise Vasquez and Natalia Vega and Michelle Atkinson and Fordham, {Jo Anne} and Olivia Henry and Archana Kedar and McNair, {Archana Valerie} and Danielle Spree and Lynn Baxter and Samantha Culler and Judy Hooker and Paula Stuart and Steven James and Rebecca Torrance and {Van Raaphorst}, Rebekah and Patricia Belt and Michele Donithan and Mika Green and Milana Isaacson and May, {Kevin Patrick} and Laura Miriel and {Van Natta}, Mark and Ivana Vaughn and Laura Wilson and Katherine Yates",

year = "2012",

month = jun,

day = "1",

doi = "10.1111/j.1365-2982.2012.01894.x",

language = "English (US)",

volume = "24",

pages = "531--e249",

journal = "Neurogastroenterology and Motility",

issn = "1350-1925",

publisher = "Wiley-Blackwell",

number = "6",

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TY - JOUR

T1 - Clinical-histological associations in gastroparesis

T2 - Results from the Gastroparesis Clinical Research Consortium

AU - Grover, M.

AU - Bernard, C. E.

AU - Pasricha, P. J.

AU - Lurken, M. S.

AU - Faussone-Pellegrini, M. S.

AU - Smyrk, T. C.

AU - Parkman, H. P.

AU - Abell, T. L.

AU - Snape, W. J.

AU - Hasler, W. L.

AU - Mccallum, R. W.

AU - Nguyen, L.

AU - Koch, K. L.

AU - Calles, J.

AU - Lee, L.

AU - Tonascia, J.

AU - Ünalp-Arida, A.

AU - Hamilton, F. A.

AU - Farrugia, G.

AU - Ullah, Nighat

AU - Bishop, Robin

AU - De Vole, Nata

AU - Greene, Mary

AU - Louiseau, Sue

AU - Parker, Shelly

AU - Pillor, Eve

AU - Ponsetto, Courtney

AU - Shetler, Katerina

AU - Shen, K. Robert

AU - Sarr, Michael

AU - Kendrick, Michael

AU - Kantor, Steven

AU - Lytes, Vanessa

AU - Palit, Amiya

AU - Sachdeva, Priyanka

AU - Simmons, Kellie

AU - Harbison, Sean

AU - Sarosiek, Irene

AU - Hejazi, Reza

AU - Vasquez, Denise

AU - Vega, Natalia

AU - Atkinson, Michelle

AU - Fordham, Jo Anne

AU - Henry, Olivia

AU - Kedar, Archana

AU - McNair, Archana Valerie

AU - Spree, Danielle

AU - Baxter, Lynn

AU - Culler, Samantha

AU - Hooker, Judy

AU - Stuart, Paula

AU - James, Steven

AU - Torrance, Rebecca

AU - Van Raaphorst, Rebekah

AU - Belt, Patricia

AU - Donithan, Michele

AU - Green, Mika

AU - Isaacson, Milana

AU - May, Kevin Patrick

AU - Miriel, Laura

AU - Van Natta, Mark

AU - Vaughn, Ivana

AU - Wilson, Laura

AU - Yates, Katherine

PY - 2012/6/1

Y1 - 2012/6/1

N2 - Background Cellular changes associated with diabetic (DG) and idiopathic gastroparesis (IG) have recently been described from patients enrolled in the Gastroparesis Clinical Research Consortium. The association of these cellular changes with gastroparesis symptoms and gastric emptying is unknown. The aim of this study was to relate cellular changes to symptoms and gastric emptying in patients with gastroparesis. Methods Earlier, using full thickness gastric body biopsies from 20 DG, 20 IG, and 20 matched controls, we found decreased interstitial cells of Cajal (ICC) and enteric nerves and an increase in immune cells in both DG and IG. Here, demographic, symptoms [gastroparesis cardinal symptom index score (GCSI)], and gastric emptying were related to cellular alterations using Pearson's correlation coefficients. Key Results Interstitial cells of Cajal counts inversely correlated with 4h gastric retention in DG but not in IG (r=-0.6, P=0.008, DG, r=0.2, P=0.4, IG). There was also a significant correlation between loss of ICC and enteric nerves in DG but not in IG (r=0.5, P=0.03 for DG, r=0.3, P=0.16, IG). Idiopathic gastroparesis with a myenteric immune infiltrate scored higher on the average GCSI (3.6±0.7 vs 2.7±0.9, P=0.05) and nausea score (3.8±0.9 vs 2.6±1.0, P=0.02) as compared to those without an infiltrate. Conclusions & Inferences In DG, loss of ICC is associated with delayed gastric emptying. Interstitial cells of Cajal or enteric nerve loss did not correlate with symptom severity. Overall clinical severity and nausea in IG is associated with a myenteric immune infiltrate. Thus, full thickness gastric biopsies can help define specific cellular abnormalities in gastroparesis, some of which are associated with physiological and clinical characteristics of gastroparesis.

AB - Background Cellular changes associated with diabetic (DG) and idiopathic gastroparesis (IG) have recently been described from patients enrolled in the Gastroparesis Clinical Research Consortium. The association of these cellular changes with gastroparesis symptoms and gastric emptying is unknown. The aim of this study was to relate cellular changes to symptoms and gastric emptying in patients with gastroparesis. Methods Earlier, using full thickness gastric body biopsies from 20 DG, 20 IG, and 20 matched controls, we found decreased interstitial cells of Cajal (ICC) and enteric nerves and an increase in immune cells in both DG and IG. Here, demographic, symptoms [gastroparesis cardinal symptom index score (GCSI)], and gastric emptying were related to cellular alterations using Pearson's correlation coefficients. Key Results Interstitial cells of Cajal counts inversely correlated with 4h gastric retention in DG but not in IG (r=-0.6, P=0.008, DG, r=0.2, P=0.4, IG). There was also a significant correlation between loss of ICC and enteric nerves in DG but not in IG (r=0.5, P=0.03 for DG, r=0.3, P=0.16, IG). Idiopathic gastroparesis with a myenteric immune infiltrate scored higher on the average GCSI (3.6±0.7 vs 2.7±0.9, P=0.05) and nausea score (3.8±0.9 vs 2.6±1.0, P=0.02) as compared to those without an infiltrate. Conclusions & Inferences In DG, loss of ICC is associated with delayed gastric emptying. Interstitial cells of Cajal or enteric nerve loss did not correlate with symptom severity. Overall clinical severity and nausea in IG is associated with a myenteric immune infiltrate. Thus, full thickness gastric biopsies can help define specific cellular abnormalities in gastroparesis, some of which are associated with physiological and clinical characteristics of gastroparesis.

KW - Clinical symptoms

KW - Enteric nervous system

KW - Gastric emptying

KW - Gastroparesis

KW - Interstitial cells of Cajal

KW - Macrophages

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SN - 1350-1925

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ER -

Clinical-histological associations in gastroparesis: Results from the Gastroparesis Clinical Research Consortium

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