Clinical guidelines for the management of pouchitis

Darrell S. Pardi; Geert D'Haens; Bo Shen; Simon Campbell; Paolo Gionchetti

doi:10.1002/ibd.21039

Clinical guidelines for the management of pouchitis

Darrell S. Pardi, Geert D'Haens, Bo Shen, Simon Campbell, Paolo Gionchetti

Gastroenterology and Hepatology

Research output: Contribution to journal › Review article › peer-review

100 Scopus citations

Abstract

When surgery is necessary in patients with ulcerative colitis, total proctocolectomy with ileal pouch-anal anastomosis (IPAA) is the procedure of choice. Several inflammatory and noninflammatory complications can occur after IPAA. Pouchitis is the most common, occurring in ≈50% of patients. Whereas "acute" pouchitis can be treated rapidly and successfully in the majority of patients, "refractory" and "chronic pouchitis" remain therapeutic challenges to patients and physicians. This article reviews the literature and offers consensus guidelines on issues related to the epidemiology, diagnosis, pathogenesis, risk factors, and treatment of pouchitis.

Original language	English (US)
Pages (from-to)	1424-1431
Number of pages	8
Journal	Inflammatory bowel diseases
Volume	15
Issue number	9
DOIs	https://doi.org/10.1002/ibd.21039
State	Published - Nov 26 2009

Keywords

Ileal pouch-anal anastomosis
Pouchitis
Ulcerative colitis

ASJC Scopus subject areas

Immunology and Allergy
Gastroenterology

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10.1002/ibd.21039

Cite this

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AU - D'Haens, Geert

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Y1 - 2009/11/26

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AB - When surgery is necessary in patients with ulcerative colitis, total proctocolectomy with ileal pouch-anal anastomosis (IPAA) is the procedure of choice. Several inflammatory and noninflammatory complications can occur after IPAA. Pouchitis is the most common, occurring in ≈50% of patients. Whereas "acute" pouchitis can be treated rapidly and successfully in the majority of patients, "refractory" and "chronic pouchitis" remain therapeutic challenges to patients and physicians. This article reviews the literature and offers consensus guidelines on issues related to the epidemiology, diagnosis, pathogenesis, risk factors, and treatment of pouchitis.

KW - Ileal pouch-anal anastomosis

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KW - Ulcerative colitis

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Clinical guidelines for the management of pouchitis

Abstract

Keywords

ASJC Scopus subject areas

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