Clinical genetics of Parkinson's disease and related disorders

Christian Wider, Zbigniew K Wszolek

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Our knowledge regarding the genetics of Parkinson's disease (PD) and parkinsonism has evolved dramatically during the past decade, with the discovery of numerous loci and genes. The LRRK2 gene has emerged as the most commonly involved in both familial and sporadic PD. Several variants in LRRK2 and SNCA have been associated with an increased risk of sporadic PD. PRKN, PINK1 and DJ1 mutations cause early-onset recessively inherited PD. Autosomal dominant dementia and parkinsonism is caused by mutations in the MAPT gene, and in the most recently discovered PGRN gene.

Original languageEnglish (US)
JournalParkinsonism and Related Disorders
Volume13
Issue numberSUPPL. 3
DOIs
StatePublished - 2007

Fingerprint

Inborn Genetic Diseases
Parkinson Disease
Parkinsonian Disorders
Genes
Mutation
Dementia

Keywords

  • Genetics
  • Parkinson's disease
  • Parkinsonism

ASJC Scopus subject areas

  • Aging
  • Clinical Neurology
  • Neurology

Cite this

Clinical genetics of Parkinson's disease and related disorders. / Wider, Christian; Wszolek, Zbigniew K.

In: Parkinsonism and Related Disorders, Vol. 13, No. SUPPL. 3, 2007.

Research output: Contribution to journalArticle

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